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Enflurane
go.drugbank.com/drugs/DB00228ApprovedVet approvedWithdrawnEnflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesSynonyms: 2-chloro-1,1,2-trifluoroethyl difluoromethyl etherTemazepam
go.drugbank.com/drugs/DB00231ApprovedTemazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal … In particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesMilrinone
go.drugbank.com/drugs/DB00235ApprovedInvestigationalHeart failure is a multifactorial condition that affects roughly 1-2% of the adult population. … [A228323] Milrinone is a second-generation bipyridine phosphodiesterase (PDE) inhibitor created through chemical modification of [amrinone].
Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 InhibitorsSynonyms: 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrileAlclometasone
go.drugbank.com/drugs/DB00240ApprovedAlclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (7alpha,11beta,16alpha)-7-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dioneMesalazine
go.drugbank.com/drugs/DB00244ApprovedInvestigationalAlthough demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent … Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation
Synonyms: 3-carboxy-4-hydroxyaniline, 5-ASAProducts: PENTASA® ENEMA 1 G, PENTASA 1 G ENEMA,7 ADETZiprasidone
go.drugbank.com/drugs/DB00246ApprovedInvestigational[A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525]
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsProducts: GEODON® CAPSULAS 80 MG, ICIN KURU TOZ ICEREN FLAKON 20MG/ML FLAKON, 1 ADETMethysergide
go.drugbank.com/drugs/DB00247ApprovedWithdrawnAn ergot derivative that is a congener of lysergic acid diethylamide.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (+)-N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide, 1-Methyl-dextro-lysergic acid (+)-1-hydroxy-2-butylamideDapsone
go.drugbank.com/drugs/DB00250ApprovedInvestigationalA sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Mixtures: Dapsone 6% / Niacinamide 4%, Dapsone 6% / Niacinamide 2% / Spironolactone 5%Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InducersTerconazole
go.drugbank.com/drugs/DB00251Approved[A178093]Due to the existence of 2 stereocentres, there are 4 possible stereoisomers for terconazole. … It is classified as a _triazole ketal derivative_.[A178096] Terconazole was initially approved by the FDA in 1987.
Mixtures: TEREX-3, Terazol 3 Dual PakCategories: Heterocyclic Compounds, 1-RingMedrysone
go.drugbank.com/drugs/DB00253ApprovedMedrysone is a corticosteroid used in ophthalmology.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 11beta-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione