Methysergide is an ergot alkaloid used for the prophylaxis of migraine and cluster headaches. An ergot derivative that is a congener of lysergic acid diethylamide.
- Mechanism
- Curator reviewed
Methysergide is serotonin antagonists acts on central nervous system (CNS), which directly stimulates the smooth muscle leading to vasoconstriction. Some alpha-adrenergic blocking activity has been reported. Suggestions have been made by investigators as to the mechanism whereby Methysergide produces its clinical effects, but this has not been finally established, although it may be related to the antiserotonin effect.
- Primary indication
- For the treatment of vascular headacheCurator reviewed
- Formula / weight
- C21H27N3O2 · 353.458 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1962
- Also known as
- 1-Methylmethylergonovine
Resolves to
KPJZHOPZRAFDTN-NQUBZZJWSA-NSMILES[H][C@@]12CC3=CN(C)C4=C3C(=CC=C4)C1=C[C@H](CN2C)C(=O)NC(CC)COWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Methysergide, and which of those have an active Phase 3 trial?
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