Alclometasone is a topical corticosteroid used to relieve the symptoms of corticosteroid-responsive dermatoses. Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
- Mechanism
- Curator reviewed
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Alclometasone initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.
- Primary indication
- For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.Curator reviewed · 1 structured indication
- Formula / weight
- C22H29ClO5 · 408.916 g/mol (avg)
- First approval
- United States, 2004
Resolves to
FJXOGVLKCZQRDN-PHCHRAKRSA-NSMILES[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])[C@H](Cl)CC2=CC(=O)C=C[C@]12CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Alclometasone, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account