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Displaying results 981 - 990 of 5925 in total
  1. Drug

    Ergometrine

    go.drugbank.com/drugs/DB01253
    ApprovedInvestigational

    An ergot alkaloid with uterine and vascular smooth muscle contractile properties.

    Synonyms: D-lysergic acid-L-propanolamide, D-lysergic acid 1-hydroxymethylethylamideCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  2. Drug

    MKC1106-PP

    go.drugbank.com/drugs/DB06030
    Experimental

    MKC1106-PP was under investigation in clinical trial NCT00423254 (Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.). … MKC1106-PP is a 3-component investigational vaccine made up of a DNA plasmid (pPRA-PSM) and 2 peptides E-PRA and E-PSM.

  3. Drug

    Triamterene

    go.drugbank.com/drugs/DB00384
    Approved

    [T28] Due to its effects on increased serum potassium levels, triamterene is associated with a risk of producing hyperkalemia.

    Mixtures: Nu-triazide Tab 50 Mg/25 mgCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  4. Drug

    Hydromorphone

    go.drugbank.com/drugs/DB00327
    ApprovedIllicitInvestigational

    Due to these modifications, it presents a very high potency and comparable side effect profile to the parent compound.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates
  5. Drug

    Tazobactam

    go.drugbank.com/drugs/DB01606
    ApprovedInvestigational

    Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with Piperacillin and Ceftolozane for the treatment of a vari...

    Mixtures: TAZPEN FOR INJECTION 4.5g/VIAL, TAZOCIN FOR INJECTION 4.5 g/vial
  6. Drug

    Lenacapavir

    go.drugbank.com/drugs/DB15673
    ApprovedInvestigational

    HIV/AIDS remains an area of concern despite the introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and patient difficulty in adhering to treatment regimens

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  7. Drug

    Pentazocine

    go.drugbank.com/drugs/DB00652
    ApprovedVet approved

    It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)

    Categories: P-glycoprotein substratesInternational brands: Talwin PX
  8. Drug

    Belzutifan

    go.drugbank.com/drugs/DB15463
    ApprovedInvestigational

    Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau (VHL) disease-associated cancers. The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medica...

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  9. Drug

    Iron protein succinylate

    go.drugbank.com/drugs/DB11209
    Approved

    Mixtures: Triveen-Duo DHA, PR Natal 430
  10. Drug

    Elvitegravir

    go.drugbank.com/drugs/DB09101
    ApprovedInvestigational

    On September 24, 2014, the FDA approved the single pill form of elvitegravir.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Inducers