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Displaying results 9921 - 9930 of 10000 in total
  1. Drug

    Mirfentanil

    go.drugbank.com/drugs/DB09175
    Experimental

    At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained … At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.

  2. Drug

    Talsupram

    go.drugbank.com/drugs/DB09191
    Experimental

    Talsupram is a selective norepinephrine reuptake inhibitor (NRI). It was under research for the treatment of depression in 1960 and 1970 but it was never marketed.

  3. Drug

    Enrofloxacin

    go.drugbank.com/drugs/DB11404
    InvestigationalVet approved

    Due to the identification of fluoroquinolone-resistant strains of _Campylobacter_, in September 2005, the FDA withdrew the approval of enrofloxacin for its use in water to treat flocks of poultry. … Enrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use.

  4. Drug

    Ilacirnon

    go.drugbank.com/drugs/DB16066
    Investigational

    Ilacirnon (CCX-140) is under investigation in clinical trial NCT01440257 (A Study to Evaluate the Effect of CCX140-B on Urinary Albumin Excretion in Subjects With Type 2 Diabetes and Albuminuria).

    Synonyms: 4-Chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonyl)-3-pyridinyl]-3-(trifluoromethyl)benzenesulfonamide
  5. Drug

    Indoramin

    go.drugbank.com/drugs/DB08950
    ApprovedWithdrawn

    It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. … Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese.

  6. Drug

    Devafidugene civaparvovec

    go.drugbank.com/drugs/DB16790
    Investigational

    Developed by Sangamo Therapeutics, Inc., devafidugene civaparvovec is being investigated for the treatment of mucopolysaccharidosis Type I (MPS I).[L46716] … Devafidugene civaparvovec is an investigational _in vivo_ genome editing product.

  7. Drug

    Carbon black

    go.drugbank.com/drugs/DB11980
    Investigational

    [A263401] Upon inhalation, carbon black has been reported to trigger an inflammatory response in the lung tissue [A263401] and has been linked to carcinogenicity.[A263406, A263411, A263416] … Produced by the incomplete combustion of hydrocarbons, carbon black is an insoluble pigment [A263396] with demonstrated adverse effects on pulmonary function.

    Synonyms: D&C BLACK NO. 2 [II], DC BLACK NO. 2
  8. Drug

    N,N-dimethylarginine

    go.drugbank.com/drugs/DB01686
    Experimental

    Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. … It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells which is closely related to L-arginine, a conditionally-essential amino acid.

    Synonyms: guanidino-N,N-dimethylarginine, N(G),N(G)-Dimethylarginine
  9. Drug

    GSK2245035

    go.drugbank.com/drugs/DB16076
    Investigational

    GSK2245035 is under investigation in clinical trial NCT02833974 (Effect of the GSK2245035 on the Allergen-induced Asthmatic Response).

  10. Drug

    Stapokibart

    go.drugbank.com/drugs/DB18990
    Investigational

    Stapokibart is under investigation in clinical trial NCT06424470 (Study on the Treatment of Prurigo Nodularis With Stapokibart Injection).