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Fluvoxamine
go.drugbank.com/drugs/DB00176ApprovedInvestigationalFluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. … Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VERLIN TABLETAS X 50 MG, VOXAMIN® TABLETA RECUBIERTABaclofen
go.drugbank.com/drugs/DB00181ApprovedInvestigationalBaclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.
Mixtures: Innoprax-5Categories: GABA-B Receptor AgonistsSuccinylcholine
go.drugbank.com/drugs/DB00202ApprovedInvestigationalSuccinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. … [A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures.
Synonyms: 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)Products: Lysthenon 0,1 g/5 ml - Injektionslösung, ETHICHOLINE INJECTION 100 mg/2 mlPyrimethamine
go.drugbank.com/drugs/DB00205ApprovedInvestigationalVet approvedOne of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsSynonyms: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine, 2,4-Diamino-5-(P-chlorophenyl)-6-ethylpyrimidineReserpine
go.drugbank.com/drugs/DB00206ApprovedWithdrawnIt has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. … An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Mixtures: Renese-R, Ser-Ap-EsCategories: P-glycoprotein inducers, P-glycoprotein inhibitorsAzithromycin
go.drugbank.com/drugs/DB00207ApprovedInvestigationalAzithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl … Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: Zmax SR, AMIZT SRAdapalene
go.drugbank.com/drugs/DB00210ApprovedInvestigational[A193521] [Tazarotene] is more efficacious than adapalene but is designated as pregnancy category X and hence is contraindicated in pregnant women. … It is also associated with _Cutibacterium acnes_ (also known as _Propionibacterium acnes_). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris.
Mixtures: GLENPALENE-C® GEL, Clindap-TSynonyms: 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acidMidodrine
go.drugbank.com/drugs/DB00211ApprovedInvestigationalAn ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AgonistsSynonyms: 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol, (±)-2-amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)acetamideTorasemide
go.drugbank.com/drugs/DB00214ApprovedInvestigationalTorasemide is a high-ceiling loop diuretic.[A174463] Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamideMoxifloxacin
go.drugbank.com/drugs/DB00218ApprovedInvestigationalMoxifloxacin is a synthetic fluoroquinolone antibiotic agent. … Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Mixtures: TQ OFTAMOX D UD®, TQ OFTAMOX® D UDCategories: 4-Quinolones, Heterocyclic Compounds, 2-Ring