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  1. Pathway

    VEGF Signaling

    smpdb.ca/view/SMP0524112
    Signaling

    Inhibitors like Bevacizumab and Aflibercept block VEGF A, preventing its effects and inhibiting angiogenesis, making them useful in treating cancers and other diseases with abnormal blood vessel growth

    Drugs: Bevacizumab · Nitric Oxide · Calcium · Mesoheme · Aflibercept
    Enzymes: Aflibercept
  2. Pathway

    Faricimab Action Pathway

    smpdb.ca/view/SMP0126914
    Drug action

    While existing treatments like aflibercept and ranibizumab focus solely on inhibiting VEGF-A, faricimab's unique mechanism involves binding to and depleting both VEGF-A and Ang-2.

    Drugs: Calcium · Faricimab