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Coagulation factor VIIa Recombinant Human

go.drugbank.com/drugs/DB00036
ApprovedInvestigational

Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically activ...

  1. Pathway

    Antihemophilic Factor Human Recombinant Action Pathway

    smpdb.ca/view/SMP0126774
    Drug action

    Antihemophilic factor, human recombinant is administered intravenously and acts to correct coagulation defects, by activating coagulation factor X and IX. … Antihemophilic factor, human recombinant of the coagulation Factor VIII, also known as Advate, Adynovate, Helixate, Kogenate, Kovaltry, Novoeight, Recombinate, to treat hemophilia A, von Willebrand disease

    Drugs: Antihemophilic factor, human recombinant · Calcium
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII
  2. Pathway

    Antihemophilic Factor Human Action Pathway

    smpdb.ca/view/SMP0126841
    Drug action

    Administered intravenously the antihemophilic factor human replaces the abnormal coagulation factor VIII, acting as a cofactor to activate coagulation factor IX and X. … It is a non-recombinant concentrate of the endogenous coagulation factor VIII, produced by reducing von Willebrand Factor antigen and purified by affinity chromatography.

    Drugs: Calcium · Antihemophilic factor human
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII
  3. Pathway

    Alteplase Action Pathway

    smpdb.ca/view/SMP0126634
    Drug action

    Alteplase is a recombinant plasminogen activator present in human tissue, also known as Activase, Cathflo and Cathflo Activase used to treat emergencies such as myocardial infarction, ischemic stroke and

    Drugs: Alteplase · Calcium
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII
  4. Indication

    Severe Bleeding

    go.drugbank.com/conditions/DBCOND0060436
    Drugs: Coagulation factor VIIa Recombinant Human
  5. Pathway

    Moroctocog Alfa Action Pathway

    smpdb.ca/view/SMP0126849
    Drug action

    Moroctocog alfa also known as Refacto AF and Xyntha, is a B-domain deleted recombinant factor VIII similar to the endogenous coagulation factor VIII. … It acts by replacing coagulation factor VIII which is deficient in those with hemophilia, this allows coagulation factor IX and X to be activated and facilitate the clotting cascade.

    Drugs: Calcium · Moroctocog alfa
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII
  6. Pathway

    Emicizumab Action Pathway

    smpdb.ca/view/SMP0126843
    Drug action

    Emicizumab also known as Hemlibra, is a humanized recombinant monoclonal antibody that mimics coagulation factor VIII and can bind to activated coagulation factor IX and X. … Emicizumab performs the function of coagulation factor VIII, with the ability to also bind to both coagulation factor IX and X.

    Drugs: Calcium · Emicizumab
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII
  7. Pathway

    Reteplase Action Pathway (new)

    smpdb.ca/view/SMP0126637
    Drug action

    Reteplase is a plasminogen activator that is created as a purified form of human tissue, also known as Retavase that is used in emergencies such as myocardial infarction, ischemic stroke and pulmonary

    Drugs: Reteplase · Calcium
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII
  8. Pathway

    Anistreplase Action Pathway (new)

    smpdb.ca/view/SMP0126638
    Drug action

    Anistreplase is a plasminogen activator created from recombinant human tissue, used in emergencies such as myocardial infarction and pulmonary emboli.

    Drugs: Anistreplase · Calcium
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII
  9. Pathway

    Tenecteplase Action Pathway (new)

    smpdb.ca/view/SMP0126640
    Drug action

    Tenecteplase is a plasminogen activator, a modified form of recombinant human tissue, also known as Metalyse and Tnkase, used in emergencies such as myocardial infarction and pulmonary emboli.

    Drugs: Tenecteplase · Calcium
    Enzymes: Coagulation factor VIIa, Coagulation factor VIII