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Displaying results 1 - 10 of 15 in total
  1. Pathway

    Human Thrombin Action Pathway

    smpdb.ca/view/SMP0126872
    Drug action

    Human thrombin is purified human thrombin, a highly specific serine protease that acts on fibrinogen to fibrin, leading to the formation of a blood clot. … Human thrombin is a platelet-activating factor also known under the brand names Artiss, Evarrest, Evicel, Evithrom, Tachosil, Tisseel and Vistaseal.

    Drugs: Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  2. Pathway

    Antihemophilic Factor Human Action Pathway

    smpdb.ca/view/SMP0126841
    Drug action

    Antihemophilic factor human, also known as Hemofil, Koate, and Wilate is used as factor VIII replacement therapy to treat hemophilia A. … Administered intravenously the antihemophilic factor human replaces the abnormal coagulation factor VIII, acting as a cofactor to activate coagulation factor IX and X.

    Drugs: Calcium · Antihemophilic factor human
    Enzymes: Thrombin, Fibrinogen beta chain
  3. Pathway

    Antihemophilic Factor Human Recombinant Action Pathway

    smpdb.ca/view/SMP0126774
    Drug action

    Antihemophilic factor, human recombinant is administered intravenously and acts to correct coagulation defects, by activating coagulation factor X and IX. … and Factor XIII deficiency.

    Drugs: Antihemophilic factor, human recombinant · Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  4. Pathway

    Coagulation Factor VII Human Action Pathway

    smpdb.ca/view/SMP0126839
    Drug action

    Coagulation factor VII human is a coagulation factor also known as Balfaxar, Beriplex, Kcentra and Octaplex to treat hemophilia and Glanzmann's thrombasthenia. … It is administered intravenously it acts in combination with tissue factor activating coagulation factor VIIa, which goes on to subsequently activate coagulation factor X and IX leading to blood clotting

    Drugs: Calcium · Coagulation factor VII human
    Enzymes: Thrombin, Fibrinogen beta chain
  5. Pathway

    Ramucirumab Action Pathway

    smpdb.ca/view/SMP0126890
    Drug action

    It is a human monoclonal antibody (IgG1) designed against VEGFR2, a transmembrane tyrosine kinase receptor expressed on endothelial cells. … , and migration of endothelial cells.

    Drugs: Calcium · Ramucirumab
    Enzymes: Thrombin, Fibrinogen beta chain
  6. Pathway

    Alteplase Action Pathway

    smpdb.ca/view/SMP0126634
    Drug action

    Alteplase is a recombinant plasminogen activator present in human tissue, also known as Activase, Cathflo and Cathflo Activase used to treat emergencies such as myocardial infarction, ischemic stroke and … Due to its nature of anticoagulant and antiplatelet activity herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.

    Drugs: Alteplase · Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  7. Pathway

    Reteplase Action Pathway (new)

    smpdb.ca/view/SMP0126637
    Drug action

    Reteplase is a plasminogen activator that is created as a purified form of human tissue, also known as Retavase that is used in emergencies such as myocardial infarction, ischemic stroke and pulmonary … Reteplase is administered intravenously and travels through the bloodstream and acts on plasminogen cleaving an arginine-valine bond converting it to its active form plasmin.

    Drugs: Reteplase · Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  8. Pathway

    Anistreplase Action Pathway (new)

    smpdb.ca/view/SMP0126638
    Drug action

    Anistreplase is a plasminogen activator created from recombinant human tissue, used in emergencies such as myocardial infarction and pulmonary emboli. … Due to its anticoagulant and antiplatelet activity, avoid herbs and supplements with similar activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.

    Drugs: Anistreplase · Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  9. Pathway

    Tenecteplase Action Pathway (new)

    smpdb.ca/view/SMP0126640
    Drug action

    Tenecteplase is a plasminogen activator, a modified form of recombinant human tissue, also known as Metalyse and Tnkase, used in emergencies such as myocardial infarction and pulmonary emboli. … Due to its anticoagulant and antiplatelet activity herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.

    Drugs: Tenecteplase · Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  10. Pathway

    Emicizumab Action Pathway

    smpdb.ca/view/SMP0126843
    Drug action

    Emicizumab also known as Hemlibra, is a humanized recombinant monoclonal antibody that mimics coagulation factor VIII and can bind to activated coagulation factor IX and X. … It is administered subcutaneously, the antibody is metabolized through endothelial cells taking up the antibodies and degrading them into small peptides and amino acids.

    Drugs: Calcium · Emicizumab
    Enzymes: Thrombin, Fibrinogen beta chain