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Displaying results 1 - 10 of 27 in total
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Erythropoietin

go.drugbank.com/drugs/DB00016
ApprovedInvestigational

Erythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. It works by promoting the division and differentiation of committed erythroid progenitors in the bone marrow [FDA Label]. Epoetin alfa (Epoge) was developed by Amgen Inc. in 1983 as the first rhEPO comm...

  1. Drug

    Epoetin beta

    go.drugbank.com/drugs/DB19434
    Investigational

    Synonyms: 1-165-ERYTHROPOIETIN (HUMAN CLONE LHEPOFL13 PROTEIN MOIETY), GLYCOFORM .BETA.
  2. Drug

    Efepoetin alfa

    go.drugbank.com/drugs/DB19197
    Investigational

    Efepoetin alfa is under investigation in clinical trial NCT04155125 (A Study of Efepoetin Alfa in Treating Anaemia Associated With Chronic Kidney Diseases Patient).

    Synonyms: Erythropoietin (human) fusion protein with immunoglobulin (synthetic hybrid fc fragment hyfc), Human erythropoietin (epoetin alfa) fused to a hybrid human immunoglobulin (ig), consisting of the fc fragment of the igg4 fused to the hinge and amino-terminus of the igd heavy chain isotype 2, produced
  3. Target

    Erythropoietin receptor

    go.drugbank.com/bio_entities/BE0000654
    TargetHumans

    Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:10388848, PubMed:2163695, PubMed:2163696, PubMed:8662939, PubMed:9774108).

    Polypeptides: Erythropoietin receptorFunction: erythropoietin receptor activity
  4. Target

    Ephrin type-A receptor 1

    go.drugbank.com/bio_entities/BE0009436
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the re...

    Synonyms: Erythropoietin-producing hepatoma receptor
  5. Target

    Eph receptors

    go.drugbank.com/bio_entities/BE0028186
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the re...

    Synonyms: Erythropoietin-producing hepatoma receptor
  6. Indication

    Erythropoietin Resistant Anemia (EPO Resistant Anemia)

    go.drugbank.com/conditions/DBCOND0161719
    Drugs: Vadadustat
    Synonyms: Erythropoietin Resistant Anemia (EPO Resistant Anemia)
  7. Drug

    Methoxy polyethylene glycol-epoetin beta

    go.drugbank.com/drugs/DB09107
    ApprovedInvestigational

    Methoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin.

    Categories: Erythropoiesis-Stimulating Agents
  8. Drug

    Darbepoetin alfa

    go.drugbank.com/drugs/DB00012
    ApprovedInvestigational

    Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

    Categories: Erythropoiesis-Stimulating Agents
  9. Drug

    Peginesatide

    go.drugbank.com/drugs/DB08894
    ApprovedWithdrawn

    Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself.

    Categories: Erythropoiesis-Stimulating Agents