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Displaying results 1 - 10 of 39 in total
  1. Drug

    Human thrombin

    go.drugbank.com/drugs/DB11571
    ApprovedInvestigational

    Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. … Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin.

    Synonyms: Human thrombin, Thrombin humanMixtures: EVICEL Fibrin Sealant (Human), EVICEL® SELLANTE DE FIBRINA HUMANA
  2. Drug

    Fibrinogen human

    go.drugbank.com/drugs/DB09222
    ApprovedInvestigational

    Fibrinogen concentrate (human) is a hematological agent. It works by replacing a specific protein in the blood, fibrinogen (factor I), that helps with blood clotting. … It is a soluble plasma glycoprotein with a molecular weight of about 340 kDa and is a physiological substrate for three enzymes: plasmin, factor XIIIa, and thrombin.

    Synonyms: Fibrinogen (human), Fibrinogen humanMixtures: EVICEL Fibrin Sealant (Human), EVICEL® SELLANTE DE FIBRINA HUMANA
  3. Drug

    Thrombin alfa

    go.drugbank.com/drugs/DB11572
    Approved

    Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. … The thrombin alfa product ultimate comes from recombinant human prethrombin-1 [L2079].

    Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsSynonyms: Thrombin (synthetic human), Human Thrombin (recombinant, glycosylated)
  4. Drug

    Thrombin

    go.drugbank.com/drugs/DB11300
    ApprovedInvestigational

    A variety of human thrombin and recombinant thrombin (ie. thrombin alfa) products are available as alternatives to using bovine thrombin. … These antibodies may subsequently cross-react with endogenous human factor V and lead to its deficiency [FDA Label].

    Synonyms: Thrombin, Thrombin bovineMixtures: BERIPLAST-P COMBI SET 1 ML TROMBİN ÇÖZELTİSİ VE 1 ML FİBRİNOJEN ÇÖZELTİSİ İÇEREN FİBRİN YAPIŞTIRICI, BERIPLAST-P COMBI SET 3 ML TROMBİN ÇÖZELTİSİ VE 1 ML FİBRİNOJEN ÇÖZELTİSİ İÇEREN FİBRİN YAPIŞTIRICI
  5. Drug

    Antihemophilic factor human

    go.drugbank.com/drugs/DB13192
    ApprovedInvestigational

    fibrinogen to fibrin, the fibrous protein that creates the scaffold of the clot. … Antihemophilic factor human is approved by the Food and Drug Administration for use in hemophilia A (classical hemophilia) for the prevention and control of hemorrhagic episodes [FDA Label].

    Synonyms: F8 protein, human, Antihemophilic factor humanMixtures: Wilate - von Willebrand Factor/Coagulation Factor VIII Complex (Human), von Willebrand Factor/Coagulation Factor VIII Complex (Human)
  6. Drug

    Coagulation factor VII human

    go.drugbank.com/drugs/DB13150
    ApprovedInvestigational

    Coagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.

    Synonyms: Factor VII human, Coagulation factor VII (human)Mixtures: OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU, Octaplex Powder and Solvent for Solution for Infusion
  7. Drug

    Coagulation factor X human

    go.drugbank.com/drugs/DB13148
    ApprovedInvestigational

    Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and children (aged 12 years and above) with hereditary Factor X deficiency. … Coagulation Factor X (Human) solution is approved by the FDA for intravenous injection under the market name Coagadex which contains normally 100 IU/mL of coagulation Factor X derived from healthy donors

    Synonyms: Coagulation factor X (human), Coagulation factor X humanMixtures: OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU, Octaplex Powder and Solvent for Solution for Infusion
  8. Drug

    Coagulation factor VIIa Recombinant Human

    go.drugbank.com/drugs/DB00036
    ApprovedInvestigational

    Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. … Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.

    Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansSynonyms: activated recombinant human factor VII, Coagulation factor VIIa Recombinant Human
  9. Drug

    Moroctocog alfa

    go.drugbank.com/drugs/DB13999
    Approved

    Other drug products with similar structure and function to Moroctocog alfa include [DB13192], which is purified Factor VIII from human pooled blood and contains both A- and B-subunits, and [DB11607], which … fibrinogen to fibrin, the fibrous protein that creates the scaffold of the clot.

    Synonyms: Human factor VIII, recombinant B-domain deleted, Antihemphilic factor, recombinant human B-domain deletedCategories: Amino Acids, Peptides, and Proteins
  10. Drug

    Eftrenonacog alfa

    go.drugbank.com/drugs/DB11608
    Approved

    It is comprised of a single molecule of human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 via recombinant DNA technology in a human embryonic kidney cell line (HEK293H … Eftrenonacog alfa was developed and marketed as Alprolix for intravenous injection by Biogen. It was first approved by the FDA in March 2014 and later approved by the EMA in May 2016.

    Synonyms: Recombinant human coagulation factor IX, FC Fusion proteinCategories: Enzymes and Coenzymes, Amino Acids, Peptides, and Proteins