Displaying drugs 2626 - 2650 of 3132 in total
Selpercatinib
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including cabozantinib, ponatinib, sorafenib, sunitinib, and vandetanib, have shown efficacy in RET-driven cancers, their...
Approved
Investigational
Matched Synonyms: … 6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine …
Matched Iupac: … 6-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl}pyridin-3-yl)pyrazolo[1,5-a]pyridine …
Matched Description: … Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and ... Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Iupac: … 6-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl}pyridin-3-yl)pyrazolo[1,5-a]pyridine …
Matched Description: … Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and ... Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Buprenorphine
Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.[A186283,A186292] It is also commonly used as an alternative to methadone for the treatment of severe opioid addiction. Buprenorphine is commercially available as the brand name product Suboxone which is...
Approved
Illicit
Investigational
Vet approved
Matched Description: … Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist ... who require larger and more frequent doses. ... an improved safety profile with a lower risk of overdose and respiratory depression. …
Matched Mixtures name: … Buprenorphine Hydrochloride and Naloxone Hydrochloride Dihydrate ... Buprenorphine Hydrochloride and Naloxone Hydrochloride Dihydrate ... Buprenorphine Hydrochloride and Naloxone Hydrochloride Dihydrate …
Matched Salts name: … Buprenorphine hydrochloride …
Matched Products: … Buprenorphine Hydrochloride ... Buprenorphine hydrochloride ... Buprenorphine Hydrochloride Sublingual …
Matched Mixtures name: … Buprenorphine Hydrochloride and Naloxone Hydrochloride Dihydrate ... Buprenorphine Hydrochloride and Naloxone Hydrochloride Dihydrate ... Buprenorphine Hydrochloride and Naloxone Hydrochloride Dihydrate …
Matched Salts name: … Buprenorphine hydrochloride …
Matched Products: … Buprenorphine Hydrochloride ... Buprenorphine hydrochloride ... Buprenorphine Hydrochloride Sublingual …
Imipenem
Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits...
Approved
Matched Synonyms: … Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid ... Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid …
Matched Iupac: … aminomethylidene)amino]ethyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid …
Matched Description: … semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and ... gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. ... product with cilastatin and [relebactam] which was recently approved by the FDA. …
Matched Mixtures name: … Imipenem and Cilastatin ... Imipenem and Cilastatin ... Imipenem and Cilastatin …
Matched Categories: … imipenem and cilastatin ... imipenem, cilastatin and relebactam …
Matched Iupac: … aminomethylidene)amino]ethyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid …
Matched Description: … semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and ... gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. ... product with cilastatin and [relebactam] which was recently approved by the FDA. …
Matched Mixtures name: … Imipenem and Cilastatin ... Imipenem and Cilastatin ... Imipenem and Cilastatin …
Matched Categories: … imipenem and cilastatin ... imipenem, cilastatin and relebactam …
Fenofibrate
Fenofibrate is a fibric acid derivative like clofibrate and gemfibrozil. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591]
Fenofibrate was granted FDA approval on 31 December 1993.
Approved
Matched Synonyms: … 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester …
Matched Description: … Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. …
Matched Mixtures name: … ACIDO FENOFIBRICO / ROSUVASTATINA 135 MG/10 MG …
Matched Categories: … pravastatin and fenofibrate ... simvastatin and fenofibrate ... rosuvastatin and fenofibrate ... pravastatin, ezetimibe and fenofibrate ... Peroxisome Proliferator Receptor alpha Agonist …
Matched Description: … Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. …
Matched Mixtures name: … ACIDO FENOFIBRICO / ROSUVASTATINA 135 MG/10 MG …
Matched Categories: … pravastatin and fenofibrate ... simvastatin and fenofibrate ... rosuvastatin and fenofibrate ... pravastatin, ezetimibe and fenofibrate ... Peroxisome Proliferator Receptor alpha Agonist …
Carbinoxamine
Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and...
Approved
Matched Synonyms: … 2-(p-chloro-α-(2-(dimethylamino)ethoxy)benzyl)pyridine …
Matched Description: … The product label for carbinoxamine as an over the counter cough and cold medicine is being modified ... to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many ... labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and …
Matched Description: … The product label for carbinoxamine as an over the counter cough and cold medicine is being modified ... to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many ... labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and …
Moricizine
An antiarrhythmia agent used primarily for ventricular rhythm disturbances.
Approved
Investigational
Withdrawn
Matched Synonyms: … [10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester …
Matched Salts name: … Moricizine hydrochloride …
Matched Salts name: … Moricizine hydrochloride …
ORC-13661
ORC-13661 is under investigation in clinical trial NCT05730283 (Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin).
Investigational
Matched Synonyms: … 4R,6S)-2-[[[(4-Chlorophenyl)amino]carbonyl]amino]-4,5,6,7-tetrahydro-5-methyl-4,6-ethanothieno[3,2-c]pyridine ... 4,6-Ethanothieno[3,2-c]pyridine-3-carboxamide, 2-[[[(4-chlorophenyl)amino]carbonyl]amino]-4,5,6,7-tetrahydro …
Cefmetazole
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Approved
Investigational
Matched Synonyms: … [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Iupac: … methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and ... It has a high rate of efficacy in many types of infection and to date no severe side effects have been …
Matched Categories: … Thiazines …
Matched Iupac: … methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and ... It has a high rate of efficacy in many types of infection and to date no severe side effects have been …
Matched Categories: … Thiazines …
Cefonicid
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Approved
Investigational
Matched Synonyms: … [1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Iupac: … sulfomethyl)-1H-1,2,3,4-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone …
Matched Categories: … Thiazines …
Matched Iupac: … sulfomethyl)-1H-1,2,3,4-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone …
Matched Categories: … Thiazines …
3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine
Experimental
Matched Name: … 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine …
Matched Iupac: … 3-[(3-methoxyphenyl)methyl]-1H-pyrrolo[2,3-b]pyridine …
Matched Iupac: … 3-[(3-methoxyphenyl)methyl]-1H-pyrrolo[2,3-b]pyridine …
Calusterone
A 17-alkylated orally active androgenic steroid. A Schedule IV drug in Canada.
Experimental
Illicit
Matched Synonyms: … 7-beta,17-alpha-Dimethyl testosterone ... 17-beta-Hydroxy-7-beta,17-alpha-dimethylandrost-4-ene-3-one …
Matched Categories: … Testosterone and derivatives …
Matched Categories: … Testosterone and derivatives …
Rifampin
Rifampin, also known as rifampicin, is a broad-spectrum antimicrobial that was first discovered in 1965 and clinically used in 1968. Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent RNA polymerase (RNAP).
Approved
Matched Synonyms: … piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate …
Matched Iupac: … -8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate …
Matched Description: … rifampicin, is a broad-spectrum antimicrobial [A263748] that was first discovered in 1965 [A263753] and ... [A263768] Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... dapsone and rifampicin ... rifampicin and isoniazid ... dapsone, rifampicin and clofazimine ... rifampicin, ethambutol and isoniazid …
Matched Iupac: … -8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate …
Matched Description: … rifampicin, is a broad-spectrum antimicrobial [A263748] that was first discovered in 1965 [A263753] and ... [A263768] Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... dapsone and rifampicin ... rifampicin and isoniazid ... dapsone, rifampicin and clofazimine ... rifampicin, ethambutol and isoniazid …
4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose
Experimental
Matched Name: … -(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose ... 4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl …
Fluconazole
Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an azole antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole...
Approved
Investigational
Matched Description: … Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and ... This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. …
Matched Categories: … 14-alpha Demethylase Inhibitors ... Imidazole and Triazole Derivatives ... Triazole and tetrazole derivatives ... azithromycin, fluconazole and secnidazole ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … FLUCONAZOL ACIS 50MG ... FLUCONAZOL ACIS 150MG …
Matched Categories: … 14-alpha Demethylase Inhibitors ... Imidazole and Triazole Derivatives ... Triazole and tetrazole derivatives ... azithromycin, fluconazole and secnidazole ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … FLUCONAZOL ACIS 50MG ... FLUCONAZOL ACIS 150MG …
Sotigalimab
Sotigalimab is under investigation in clinical trial NCT03123783 (CD40 Agonistic Antibody APX005M in Combination With Nivolumab).
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G1 (270-GLUTAMIC ACID, C-TERMINAL-LYSINE-CLIPPED), ANTI-(HUMAN CD40 ANTIGEN) (HUMAN-ORYCTOLAGUS …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Exlinkibart
Investigational
Matched Synonyms: … Immunoglobulin G1 (de-236-glycine,267-glutamic acid,de-C-terminal lysine), anti-(human tumor necrosis …
Piperacillin
Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics.
Approved
Matched Synonyms: … carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid …
Matched Iupac: … carbonyl)amino]-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid …
Matched Mixtures name: … Piperacillin and Tazobactam ... Piperacillin and Tazobactam ... Piperacillin and Tazobactam …
Matched Iupac: … carbonyl)amino]-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid …
Matched Mixtures name: … Piperacillin and Tazobactam ... Piperacillin and Tazobactam ... Piperacillin and Tazobactam …
Bisoprolol
Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor...
Approved
Matched Synonyms: … (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol …
Matched Description: … A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and ... alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and ... It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful …
Matched Mixtures name: … Bisoprolol Fumarate and Hydrochlorothiazide ... Bisoprolol Fumarate and Hydrochlorothiazide ... Bisoprolol Fumarate and Hydrochlorothiazide …
Matched Categories: … bisoprolol and acetylsalicylic acid ... Beta Blocking Agents and Thiazides ... ramipril and bisoprolol ... bisoprolol and thiazides ... perindopril and bisoprolol …
Matched Description: … A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and ... alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and ... It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful …
Matched Mixtures name: … Bisoprolol Fumarate and Hydrochlorothiazide ... Bisoprolol Fumarate and Hydrochlorothiazide ... Bisoprolol Fumarate and Hydrochlorothiazide …
Matched Categories: … bisoprolol and acetylsalicylic acid ... Beta Blocking Agents and Thiazides ... ramipril and bisoprolol ... bisoprolol and thiazides ... perindopril and bisoprolol …
O1-Methyl-4-Deoxy-4-Thio-Alpha-D-Glucose
Experimental
Matched Name: … O1-Methyl-4-Deoxy-4-Thio-Alpha-D-Glucose …
Gefurulimab
Gefurulimab is under investigation in clinical trial NCT05556096 (Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis).
Investigational
Matched Synonyms: … MONOCLONAL ALXN1720 SINGLE-DOMAIN VHH FRAGMENT) FUSION PROTEIN WITH PEPTIDE LINKER (SYNTHETIC 15 AMINO-ACID …
Matched Description: … Gefurulimab is under investigation in clinical trial NCT05556096 (Safety and Efficacy of ALXN1720 in …
Matched Description: … Gefurulimab is under investigation in clinical trial NCT05556096 (Safety and Efficacy of ALXN1720 in …
Nedocromil
A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
Approved
Investigational
Matched Synonyms: … 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid …
Matched Iupac: … 9-ethyl-4,6-dioxo-10-propyl-4H,6H,9H-chromeno[7,6-b]pyridine-2,8-dicarboxylic acid …
Matched Description: … are associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and …
Matched Categories: … Decongestants and Antiallergics …
Matched Iupac: … 9-ethyl-4,6-dioxo-10-propyl-4H,6H,9H-chromeno[7,6-b]pyridine-2,8-dicarboxylic acid …
Matched Description: … are associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and …
Matched Categories: … Decongestants and Antiallergics …
K-777
Investigational
Matched Synonyms: … 4-methylpiperazine-1-carboxylic acid [1-(3-benzenesufonyl-1-phenethylallyl-carbamoyl)-2-phenylethyl] ... 4-methylpiperazine-1-carboxylic acid(1-((3-benzenesufonyl-1-phenethylallyl)carbamoyl)-2-phenylethyl)amide …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Aromatic ... Amino Acids, Essential …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Aromatic ... Amino Acids, Essential …
Lumefantrine
Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including...
Approved
Matched Synonyms: … dl-Benflumelol …
Matched Description: … and may be used to treat infections caused by P. falciparum and unidentified Plasmodium …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... artemether and lumefantrine …
Matched Description: … and may be used to treat infections caused by P. falciparum and unidentified Plasmodium …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... artemether and lumefantrine …
Fingolimod
Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially approved by the FDA in 2010. Fingolimod was also...
Approved
Investigational
Matched Description: … neurological, physical, and cognitive effects. ... Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe ... It was developed by Novartis and initially approved by the FDA in 2010. …
Matched Salts name: … Fingolimod hydrochloride …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Fingolimod Hydrochloride …
Matched Salts name: … Fingolimod hydrochloride …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Fingolimod Hydrochloride …
Displaying drugs 2626 - 2650 of 3132 in total