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Displaying drugs 3376 - 3400 of 4099 in total

Hexobarbital

A barbiturate that is effective as a hypnotic and sedative.
Experimental
Matched Synonyms: … 5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid …
Matched Description: … A barbiturate that is effective as a hypnotic and sedative. …
Matched Salts name: … Hexobarbital sodium …
Matched Categories: … Hypnotics and Sedatives …

Meningococcal polysaccharide vaccine group C

Meningococcal group C polysaccharide is group-specific polysaccharide antigens extracted and purified from Neisseria meningitidis serogroup C. N. meningitidis is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia. It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup C.
Approved
Experimental
Investigational
Matched Synonyms: … Neisseria meningitidis group C (strain C11) oligosaccharide CRM-197 adipic acid conjugate …
Matched Description: … *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia ... Meningococcal group C polysaccharide is group-specific polysaccharide antigens extracted and purified …
Matched Mixtures name: … Menveo Powder and Solution for Solution for Injection ... NIMENRIX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... Nimenrix Powder and Solvent for Solution for Injection …

Vilamakitug

Vilamakitug is under investigation in clinical trial NCT05201352 (Evaluation of Efficacy of Trifluridine/tipiracil Plus an Anti-il-1α True Human Antibody Versus Trifluridine/tipiracil Plus Placebo in Metastatic Colorectal Cancer Patients After Failure of Oxaliplatin, Irinotecan, Fluoropyrimidine).
Investigational
Matched Synonyms: … Immunoglobulin g4, anti-(human interleukin 1.alpha.) …

2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium

Experimental
Matched Name: … 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium …
Matched Iupac: … 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium …

Mitiperstat

Mitiperstat is under investigation in clinical trial NCT05492877 (An Efficacy and Safety Study of Mitiperstat (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.).
Investigational
Matched Synonyms: … 1-({2-[(1R)-1-aminoethyl]-4-chlorophenyl}methyl)-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d] ... 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-1,2,3,5-tetrahydro …
Matched Description: … Mitiperstat is under investigation in clinical trial NCT05492877 (An Efficacy and Safety Study of Mitiperstat …

(2R,3S,5S)-2-(Hydroxymethyl)-5-[(2-sulfoethyl)carbamoyl]-3-pyrrolidiniumyl 2-acetamido-2-deoxy-4-O-sulfo-beta-D-glucopyranoside

Experimental
Matched Name: … 3S,5S)-2-(Hydroxymethyl)-5-[(2-sulfoethyl)carbamoyl]-3-pyrrolidiniumyl 2-acetamido-2-deoxy-4-O-sulfo-beta-D-glucopyranoside …

Dasabuvir

Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Synonyms: … Sodium 3-(3-tert-butyl-4-methoxy-5-{6­ [(methylsulfonyl)amino]naphthalene-2-yl}phenyl)-2,6-dioxo-3,6 …
Matched Description: … categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and ... [DB00503] for genotype 1b and with [DB00811] for genotype 1a of Hepatitis C [L852]. ... Dasabuvir is a non-nucleoside NS5B inhibitor which binds to the palm domain of NS5B and induces a conformational …
Matched Salts name: … Dasabuvir sodium ... Dasabuvir sodium monohydrate …
Matched Categories: … dasabuvir, ombitasvir, paritaprevir and ritonavir …

Oxypurinol

Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol.
Investigational
Matched Synonyms: … 1H-Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione …
Matched Iupac: … 1H,2H,4H,5H,6H-pyrazolo[3,4-d]pyrimidine-4,6-dione …
Matched Description: … Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol. …
Matched Categories: … Xanthine Oxidase Inhibitors …

Zilebesiran

Zilebesiran is under investigation in clinical trial NCT06272487 (Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)).
Investigational
Matched Synonyms: … (2S,4R)-1-{1-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2- acetamido-2-deoxy-β-D-galactopyranosyl …
Matched Description: … clinical trial NCT06272487 (Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and …

Pegadricase

Pegadricase is under investigation in clinical trial NCT01021241 (Safety and Efficacy Study of Intravenous Uricase-PEG 20).
Investigational
Matched Synonyms: … PEGylated recombinant candida urate oxidase …
Matched Description: … Pegadricase is under investigation in clinical trial NCT01021241 (Safety and Efficacy Study of Intravenous …

CB-5083

Investigational
Matched Synonyms: … 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide ... 1-(7,8-Dihydro-4-((phenylmethyl)amino)-5H-pyrano(4,3-d)pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide …
Matched Iupac: … 1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide …

Simvastatin

Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production...
Approved
Matched Synonyms: … 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy …
Matched Description: … hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid ... belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and ... referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). …
Matched Mixtures name: … EXOTIB-DUO ... EZETIMIBE E SIMVASTATINA DOC GENERICI ... EZETIMIBE E SIMVASTATINA DOC GENERICI …
Matched Categories: … simvastatin and acetylsalicylic acid ... simvastatin, acetylsalicylic acid and ramipril ... simvastatin and ezetimibe ... sitagliptin and simvastatin ... simvastatin and fenofibrate …
Matched Products: … Dom-simvastatin ... SIMVASTATINA DOC ... SIMVASTATINA DOC GENERICI …

Tobevibart

Tobevibart is under investigation in clinical trial NCT05612581 (A Platform Study to Evaluate Investigational Therapies in Chronic Hepatitis B Infection).
Investigational
Matched Synonyms: … Immunoglobulin G1 [238-alanine,332-leucine,334-glutamic acid,430-leucine,436-serine], anti-(hepatitis …

Finasteride

Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as dutasteride, which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects. Finasteride is an orally active drug...
Approved
Matched Description: … [A178159] In the treatment of benign prostate hyperplasia, alpha-blockers such as [tamsulosin] and [terazosin ... Finasteride is a synthetic 4-azasteroid compound [L10565] and specific inhibitor of steroid Type II 5α-reductase ... by _in situ_ high levels of DHT. …
Matched Mixtures name: … Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% ... Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025% …
Matched Categories: … 5-alpha Reductase Inhibitors ... Adrenergic alpha-Antagonists ... Genito Urinary System and Sex Hormones ... Skin and Mucous Membrane Agents ... doxazosin and finasteride …
Matched Products: … FOLIX 1 MG TABLETAS ... Dom-finasteride ... FINASTERIDE DOC …

Carbinoxamine

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and...
Approved
Matched Synonyms: … 2-(p-chloro-α-(2-(dimethylamino)ethoxy)benzyl)pyridine …
Matched Description: … to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many ... The product label for carbinoxamine as an over the counter cough and cold medicine is being modified ... labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and …
Matched Mixtures name: … Coldec DS ... Rondamine DM ... Carbinoxamine/Pseudoephedrine/DM …

TAK-733

TAK-733 has been used in trials studying the treatment of Advanced Metastatic Melanoma, Advanced Nonhematologic Malignancies, and Advanced Non-hematologic Malignancies.
Investigational
Matched Synonyms: … (R)-3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO(2,3-D)PYRIMIDINE-4,7 ... 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine …
Matched Iupac: … (2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-3H,4H,7H,8H-pyrido[2,3-d] …
Matched Description: … trials studying the treatment of Advanced Metastatic Melanoma, Advanced Nonhematologic Malignancies, and …

Inavolisib

Inavolisib (GDC-0077) is under investigation in clinical trial NCT03006172 (To Evaluate the Safety, Tolerability, and Pharmacokinetics of GDC-0077 Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer).
Investigational
Matched Synonyms: … (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin- ... propanamide, 2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin …
Matched Description: … GDC-0077) is under investigation in clinical trial NCT03006172 (To Evaluate the Safety, Tolerability, and ... Endocrine and Targeted Therapies in Participants With Breast Cancer). ... Pharmacokinetics of GDC-0077 Single Agent in Participants With Solid Tumors and in Combination With …

Imipenem

Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits...
Approved
Matched Synonyms: … Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid ... Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid …
Matched Iupac: … aminomethylidene)amino]ethyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid …
Matched Description: … [label] It is stable to many beta-lactamases. ... semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and ... gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. …
Matched Mixtures name: … IMIPEMEM CILASTATINA SODICA ... IMIPENEM MONOHYDRATE - CILASTATIN SODIUM ... IMIPENEM MONOHYDRATE / CILASTATIN SODIUM …
Matched Categories: … imipenem and cilastatin ... imipenem, cilastatin and relebactam ... beta-Lactams ... Beta-Lactam Antibacterials …

(+)-menthol

Experimental
Matched Synonyms: … D-menthol …
Matched Mixtures name: … DR JOE LAB PMS Menstrual Pain Relief Cream DR JOE LAB ... DR JOE LAB PMS Menstrual Pain Relief Cream DR JOE LAB …

Fenofibrate

Fenofibrate is a fibric acid derivative like clofibrate and gemfibrozil. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993.
Approved
Matched Synonyms: … 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester …
Matched Description: … Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. …
Matched Mixtures name: … ACIDO FENOFIBRICO / ROSUVASTATINA 135 MG/10 MG …
Matched Categories: … pravastatin and fenofibrate ... simvastatin and fenofibrate ... rosuvastatin and fenofibrate ... pravastatin, ezetimibe and fenofibrate ... Peroxisome Proliferator Receptor alpha Agonist …
Matched Products: … Dom-fenofibrate Supra ... Dom-fenofibrate Micro ... FENOFIBRATO DOC GENERICI …

Histrelin

Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Synonyms: … [(im-Bzl)-D-His6,Pro9-NEt]-gonadotropin releasing hormone ... L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-Nim-benzyl-histidyl-L-leucyl-L-arginyl-L-proline ... 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide …
Matched Iupac: … propanamido]-4-methylpentanamido]-5-carbamimidamidopentanoyl]-N-ethylpyrrolidine-2-carboxamide; bis(acetic acid …
Matched Description: … to their capacity to reduce LH levels and the concentration of sex steroids. ... GnRH agonists are the first line of treatment for children with central precocious puberty (CPP) due ... implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate …
Matched Salts name: … Histrelin acetate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

ORC-13661

ORC-13661 is under investigation in clinical trial NCT05730283 (Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin).
Investigational
Matched Synonyms: … 4R,6S)-2-[[[(4-Chlorophenyl)amino]carbonyl]amino]-4,5,6,7-tetrahydro-5-methyl-4,6-ethanothieno[3,2-c]pyridine ... 4,6-Ethanothieno[3,2-c]pyridine-3-carboxamide, 2-[[[(4-chlorophenyl)amino]carbonyl]amino]-4,5,6,7-tetrahydro …

Cefmetazole

A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Approved
Investigational
Matched Synonyms: … [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Iupac: … methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and ... It has a high rate of efficacy in many types of infection and to date no severe side effects have been …
Matched Salts name: … Cefmetazole sodium …
Matched Categories: … Thiazines ... beta-Lactams …

1-Deoxy-D-xylulose 5-phosphate

1-Deoxy-D-xylulose 5-phosphate is a solid. This compound belongs to the pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. The proteins that 1-Deoxy-D-xylulose 5-phosphate targets include 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and pyridoxine 5'-phosphate synthase. 1-Deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway.
Experimental
Matched Name: … 1-Deoxy-D-xylulose 5-phosphate …
Matched Iupac: … {[(2R,3S)-2,3-dihydroxy-4-oxopentyl]oxy}phosphonic acid …
Matched Description: … and pyridoxine 5'-phosphate synthase. 1-Deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate ... The proteins that 1-Deoxy-D-xylulose 5-phosphate targets include 1-Deoxy-D-xylulose 5-phosphate reductoisomerase ... 1-Deoxy-D-xylulose 5-phosphate is a solid. This compound belongs to the pentose phosphates. …

1,6-Di-O-Phosphono-D-Allitol

Experimental
Matched Name: … 1,6-Di-O-Phosphono-D-Allitol …
Matched Iupac: … {[(2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexyl]oxy}phosphonic acid …
Displaying drugs 3376 - 3400 of 4099 in total