DB01355ExperimentalSmall molecule
A barbiturate that is effective as a hypnotic and sedative.
- Mechanism
- Curator reviewed
Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
- Primary indication
- For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.Curator reviewed
- Formula / weight
- C12H16N2O3 · 236.267 g/mol (avg)
- Also known as
- Hexobarbitone · Methexenyl · Methylhexabital
- Code names
- NSC-71929
Resolves to
Clinical / RWD
Structure
InChIKey
UYXAWHWODHRRMR-UHFFFAOYSA-NSMILESCN1C(=O)NC(=O)C(C)(C1=O)C1=CCCCC1What you can answer from here — as of September 23, 2026
10Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Hexobarbital, and which of those have an active Phase 3 trial?
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