Displaying drugs 3676 - 3700 of 4438 in total
S-23
An androgen receptor modulator.
Experimental
Matched Synonyms: … (2S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide …
Matched Iupac: … (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide …
Matched Iupac: … (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide …
Sonidegib
Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Approved
Investigational
Matched Synonyms: … N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide …
Matched Iupac: … N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl] …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Iupac: … N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl] …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
TAK-075 Free base
Investigational
Matched Synonyms: … Pyrazolo(1,5-a)pyrimidine-3-carboxamide, n-(1-ethyl-1-(4-ethylphenyl)propyl)-4,5,6,7-tetrahydro-2,7,7 …
Matched Iupac: … (5R)-N-[3-(4-ethylphenyl)pentan-3-yl]-2,7,7-trimethyl-5-phenyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine- …
Matched Iupac: … (5R)-N-[3-(4-ethylphenyl)pentan-3-yl]-2,7,7-trimethyl-5-phenyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine- …
Uracil mustard
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
Approved
Matched Synonyms: … 5-N,N-bis(2-chloroethyl)aminouracil …
Matched Description: … and bone marrow damage. ... It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … and bone marrow damage. ... It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Fimepinostat
Fimepinostat (CUDC-907) has been used in trials studying the treatment of lymphoma, solid tumors, breast cancer, multiple myeloma, and NUT midline carcinoma, among others.
Investigational
Matched Synonyms: … 5-pyrimidinecarboxamide, N-hydroxy-2-[[[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin ... N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino …
Matched Iupac: … N-hydroxy-2-({[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl …
Matched Description: … been used in trials studying the treatment of lymphoma, solid tumors, breast cancer, multiple myeloma, and ... NUT midline carcinoma, among others. …
Matched Iupac: … N-hydroxy-2-({[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl …
Matched Description: … been used in trials studying the treatment of lymphoma, solid tumors, breast cancer, multiple myeloma, and ... NUT midline carcinoma, among others. …
Tuspetinib
Tuspetinib (HM-43239) is under investigation in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia).
Investigational
Matched Synonyms: … 2-Pyrimidinamine, 5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl-1-piperazinyl)methyl)phenyl)-4-( ... 5-Chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazine-1-yl) methyl) phenyl)-4-(6-methyl-1hindol …
Matched Iupac: … 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol- …
Matched Description: … in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and …
Matched Iupac: … 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol- …
Matched Description: … in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and …
Atuliflapon
Atuliflapon is under investigation in clinical trial NCT05251259 (Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-severe Uncontrolled Asthma).
Investigational
Matched Synonyms: … (1r,2r)-2-(4-(3-methyl-1h-pyrazol-5-yl)benzoyl)-n-(4-oxo-6,7-dihydro-5h-pyrazolo(1,5-a)pyrazine-3-yl) ... Cyclohexanecarboxamide, 2-(4-(5-methyl-1h-pyrazol-3-yl)benzoyl)-n-(4,5,6,7-tetrahydro-4-oxopyrazolo(1,5 …
Matched Description: … Atuliflapon is under investigation in clinical trial NCT05251259 (Study to Assess the Efficacy and Safety …
Matched Description: … Atuliflapon is under investigation in clinical trial NCT05251259 (Study to Assess the Efficacy and Safety …
Sebetralstat
Investigational
Matched Synonyms: … 1H-Pyrazole-4-carboxamide, N-[(3-fluoro-4-methoxy-2-pyridinyl)methyl]-3-methoxymethyl)-1-[[4-[(2-oxo- ... N-[(3-fluoro-4-methoxypyridin-2-yl) methyl]-3-(methoxymethyl)-1-({4-[(2-oxo-1,2-dihydropyridin-1-yl) ... N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1(2H)-yl)methyl]phenyl …
Matched Iupac: … N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxo-1,2-dihydropyridin-1-yl)methyl …
Matched Iupac: … N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxo-1,2-dihydropyridin-1-yl)methyl …
N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDE
Experimental
Matched Name: … N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDE …
Matched Iupac: … N-ethyl-3-methyl-N-(propan-2-yl)-5-[(2S)-2-[(pyridin-4-yl)amino]propoxy]benzamide …
Matched Iupac: … N-ethyl-3-methyl-N-(propan-2-yl)-5-[(2S)-2-[(pyridin-4-yl)amino]propoxy]benzamide …
N~2~-[(BENZYLOXY)CARBONYL]-N-[(1S,2S)-2-HYDROXY-1-(4-HYDROXYBENZYL)PROPYL]-L-LEUCINAMIDE
Experimental
Matched Name: … N~2~-[(BENZYLOXY)CARBONYL]-N-[(1S,2S)-2-HYDROXY-1-(4-HYDROXYBENZYL)PROPYL]-L-LEUCINAMIDE …
Matched Iupac: … benzyl N-[(1S)-1-{[(2S,3S)-3-hydroxy-1-(4-hydroxyphenyl)butan-2-yl]carbamoyl}-3-methylbutyl]carbamate …
Matched Iupac: … benzyl N-[(1S)-1-{[(2S,3S)-3-hydroxy-1-(4-hydroxyphenyl)butan-2-yl]carbamoyl}-3-methylbutyl]carbamate …
4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide
Experimental
Matched Name: … 4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide …
Matched Iupac: … N-[(4-fluorophenyl)methyl]-4-sulfamoylbenzamide …
Matched Iupac: … N-[(4-fluorophenyl)methyl]-4-sulfamoylbenzamide …
N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide
Experimental
Matched Name: … N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide …
Matched Iupac: … N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide …
Matched Iupac: … N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide …
4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide
Experimental
Matched Name: … 4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide …
Matched Iupac: … N-[(2,4-difluorophenyl)methyl]-4-sulfamoylbenzamide …
Matched Iupac: … N-[(2,4-difluorophenyl)methyl]-4-sulfamoylbenzamide …
5-Hydroxy-N-Propargyl-1(R)-Aminoindan
Experimental
Matched Name: … 5-Hydroxy-N-Propargyl-1(R)-Aminoindan …
N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Experimental
Matched Name: … N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide …
Matched Iupac: … N-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide …
Matched Iupac: … N-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide …
ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE
Experimental
Matched Name: … ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE …
Matched Iupac: … {[(Z)-[1-(ethylsulfanyl)-2-phenylethylidene]amino]oxy}sulfonic acid …
Matched Iupac: … {[(Z)-[1-(ethylsulfanyl)-2-phenylethylidene]amino]oxy}sulfonic acid …
(2R)-2-PHENYL-N-PYRIDIN-4-YLBUTANAMIDE
Experimental
Matched Name: … (2R)-2-PHENYL-N-PYRIDIN-4-YLBUTANAMIDE …
Matched Iupac: … (2R)-2-phenyl-N-(pyridin-4-yl)butanamide …
Matched Iupac: … (2R)-2-phenyl-N-(pyridin-4-yl)butanamide …
1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
Experimental
Matched Name: … 1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamide …
Matched Iupac: … (2S)-1-butanoyl-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-2-carboxamide …
Matched Iupac: … (2S)-1-butanoyl-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-2-carboxamide …
D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide
Experimental
Matched Name: … D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide …
Matched Iupac: … (2S)-1-[(2R)-2-amino-3-phenylpropanoyl]-N-[(3-methylphenyl)methyl]pyrrolidine-2-carboxamide …
Matched Iupac: … (2S)-1-[(2R)-2-amino-3-phenylpropanoyl]-N-[(3-methylphenyl)methyl]pyrrolidine-2-carboxamide …
2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide
Experimental
Matched Name: … 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide …
Matched Iupac: … 2-(4-fluorobenzenesulfonamido)-N-oxoacetamide …
Matched Iupac: … 2-(4-fluorobenzenesulfonamido)-N-oxoacetamide …
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE
Experimental
Matched Name: … N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE …
Matched Iupac: … N-[2-(4-sulfamoylphenyl)ethyl]acetamide …
Matched Iupac: … N-[2-(4-sulfamoylphenyl)ethyl]acetamide …
N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE
Experimental
Matched Name: … N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE …
Matched Iupac: … 3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide …
Matched Iupac: … 3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide …
4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
Experimental
Matched Name: … 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN …
Entrectinib
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. Entrectinib's...
Approved
Investigational
Matched Synonyms: … N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide …
Matched Iupac: … N-{5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl}-4-(4-methylpiperazin-1-yl)-2-[(oxan-4-yl)amino]benzamide …
Matched Description: … kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. ... cell lung cancer and NTRK gene fusion positive solid tumors. ... This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Tyrosine Kinase Inhibitors ... ROS1 tyrosine kinase inhibitors …
Matched Iupac: … N-{5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl}-4-(4-methylpiperazin-1-yl)-2-[(oxan-4-yl)amino]benzamide …
Matched Description: … kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. ... cell lung cancer and NTRK gene fusion positive solid tumors. ... This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Tyrosine Kinase Inhibitors ... ROS1 tyrosine kinase inhibitors …
Displaying drugs 3676 - 3700 of 4438 in total