Displaying drugs 4551 - 4575 of 8282 in total
PF-06260414
PF-06260414 is under investigation in clinical trial NCT02070939 (Study To Evaluate Safety And Tolerability Of Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects).
Investigational
Matched Description: … Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects). ... 06260414 is under investigation in clinical trial NCT02070939 (Study To Evaluate Safety And Tolerability Of …
ABP-700
ABP-700 is under investigation in clinical trial NCT02800590 (Study to Investigate the Safety and Efficacy of 3 Dosing Regimens of ABP-700 for Procedural Sedation in Adult Participants Undergoing Colonoscopy).
Investigational
Matched Description: … is under investigation in clinical trial NCT02800590 (Study to Investigate the Safety and Efficacy of ... 3 Dosing Regimens of ABP-700 for Procedural Sedation in Adult Participants Undergoing Colonoscopy). …
Beclomethasone 17-monopropionate
An ester of beclomethasone.
Experimental
Matched Description: … An ester of beclomethasone. …
Phosphoaminophosphonic Acid-Adenylate Ester
5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation. [PubChem]
Experimental
Matched Description: … ATP-dependent reactions of oxidative phosphorylation. ... An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a ... It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits …
Veglin
VEGF-AS (Veglin) is an anti-angiogenesis non-chemotherapy drug (angiogenesis inhibitor) that was developed by VasGene Therapeutics, Inc. for the treatment of a variety of malignancies including mesothelioma. Veglin is one of several newly developed non-chemotherapy drugs being tested for possible utilization in the ongoing struggle to combat malignant mesothelioma.
Investigational
Matched Description: … a variety of malignancies including mesothelioma. ... Veglin is one of several newly developed non-chemotherapy drugs being tested for possible utilization ... non-chemotherapy drug (angiogenesis inhibitor) that was developed by VasGene Therapeutics, Inc. for the treatment of …
Ripasudil
Ripasudil, as hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor used for the treatment of glaucoma and ocular hypertension. It was first approved for treatment in Japan in September 2014. This medication is available in the form of a 0.4% eye drop solution under the...
Experimental
Matched Description: … specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor used for the treatment of ... This medication is available in the form of a 0.4% eye drop solution under the brand name Glanatec. …
MBO7133
MB07133 is a HepDirect prodrug of an activated form of cytarabine (araC), an anti-cancer drug that is used to treat leukemia but is ineffective against primary liver cancer. AraC's anti-cancer activity is associated with its ability to be converted to its biologically active form, araCTP. However, araC is only slowly...
Investigational
Matched Description: … MB07133 is a HepDirect prodrug of an activated form of cytarabine (araC), an anti-cancer drug that is ... activation pathway of the drug. ... , araC is only slowly converted to araCTP in the liver or in primary liver tumors due to low levels of …
Tienilic acid
Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982)
Withdrawn
Matched Description: … ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of …
Glutaral
One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
Experimental
Matched Description: … One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive …
Butyrylthiocholine
A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity. [PubChem]
Experimental
Matched Description: … It is used as a reagent in the determination of butyrylcholinesterase activity. [PubChem] ... A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate …
HX-1171
Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety, Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects).
Investigational
Matched Description: … , Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects). ... Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety …
PF-05089771
PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).
Investigational
Matched Description: … PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee). ... PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of …
Yttrium Y-90 clivatuzumab tetraxetan
Yttrium Y-90 clivatuzumab tetraxetan is under investigation in clinical trial NCT00603863 (Safety and Efficacy Study of Different Doses of 90Y-hPAM4 Combined With Gemcitabine in Pancreatic Cancer).
Investigational
Matched Description: … Different Doses of 90Y-hPAM4 Combined With Gemcitabine in Pancreatic Cancer). ... clivatuzumab tetraxetan is under investigation in clinical trial NCT00603863 (Safety and Efficacy Study of …
Gusacitinib
Gusacitinib is under investigation in clinical trial NCT02550678 (A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma).
Investigational
Matched Description: … of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma). ... Gusacitinib is under investigation in clinical trial NCT02550678 (A Study of the Efficacy and Safety …
2-(5-fluoro-pentyl)-2-methyl-malonic-acid
2-(5-fluoro-pentyl)-2-methyl-malonic-acid is under investigation in clinical trial NCT00696943 (18F ML-10 for Early Detection of Response of Brain Metastases to SRS).
Investigational
Matched Description: … Response of Brain Metastases to SRS). ... methyl-malonic-acid is under investigation in clinical trial NCT00696943 (18F ML-10 for Early Detection of …
Netakimab
Netakimab is under investigation in clinical trial NCT03447704 (International Multicenter Comparative Randomized Placebo-controlled Clinical Study of Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis).
Investigational
Matched Description: … Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis). ... trial NCT03447704 (International Multicenter Comparative Randomized Placebo-controlled Clinical Study of …
Mitiperstat
Mitiperstat is under investigation in clinical trial NCT05492877 (An Efficacy and Safety Study of Mitiperstat (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.).
Investigational
Matched Description: … (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.). ... Mitiperstat is under investigation in clinical trial NCT05492877 (An Efficacy and Safety Study of Mitiperstat …
Citraconic acid
Citraconic acid is one of the isomeric dicarboxylic acids produced by the distillation of citric acid, or as metabolites by microorganisms, cis-CH3-C(CO2H)=CHCO2H; the trans-isomer is mesaconic acid.
Experimental
Matched Description: … Citraconic acid is one of the isomeric dicarboxylic acids produced by the distillation of citric acid …
9CUAB30
9 Cuab30 has been used in trials studying the treatment and prevention of HER2/Neu Positive, HER2/Neu Negative, No Evidence of Disease, Estrogen Receptor Negative, and estrogen receptor positive, among others.
Investigational
Matched Description: … 9 Cuab30 has been used in trials studying the treatment and prevention of HER2/Neu Positive, HER2/Neu ... Negative, No Evidence of Disease, Estrogen Receptor Negative, and estrogen receptor positive, among …
ST-101
ST-101 is a small peptide antagonist of C/EBPβ and T-type calcium channel activator. ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease.
Investigational
Matched Description: … ST-101 is a small peptide antagonist of C/EBPβ and T-type calcium channel activator. ... ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease. …
Albinterferon Alfa-2B
Albumin-interferon alpha (Albuferon) is a novel, long-acting form of interferon alpha. Recombinant interferon alpha is approved for the treatment of hepatitis C, hepatitis B, and a broad range of cancers. Human Genome Sciences modified interferon alpha to improve its pharmacological properties by using the company's proprietary albumin fusion technology. Human...
Investigational
Matched Description: … of cancers. ... Albumin-interferon alpha (Albuferon) is a novel, long-acting form of interferon alpha. ... Recombinant interferon alpha is approved for the treatment of hepatitis C, hepatitis B, and a broad range …
N,N-dimethylarginine
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells which is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a...
Experimental
Matched Description: … It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human ... ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and …
Tetrathiomolybdate
Tetrathiomolybdate is an oral, small-molecule, anticopper agent that is highly specific for lowering the levels of free copper in serum. COPREXA has completed pivotal clinical trials for the treatment of neurologic Wilson's disease. It is also developed for fibrotic disorders based upon the rationale that the fibrotic disease process is...
Investigational
Matched Description: … COPREXA has completed pivotal clinical trials for the treatment of neurologic Wilson's disease. ... Tetrathiomolybdate is an oral, small-molecule, anticopper agent that is highly specific for lowering the levels of ... disorders based upon the rationale that the fibrotic disease process is dependent upon the availability of …
IDM-4
IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of Leukemia. It is a monoclonal antibody-specific antigen that can selectively target cancer-affected cells by coupling with tumor cell-killing MAK cells, which are derived from the patient's own monocytes. Trials of this drug have most likely...
Investigational
Matched Description: … IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of ... Trials of this drug have most likely been discontinued by the manufacturer. …
Displaying drugs 4551 - 4575 of 8282 in total