Displaying drugs 451 - 475 of 8039 in total
Menthyl salicylate
Menthyl salicylate is an ester of menthol and salicylic acid .
This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains) .
Approved
Matched Description: … Menthyl salicylate is an ester of menthol and salicylic acid [L2808]. ... This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, …
Istradefylline
Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A2A receptors in the basal ganglia. This region of the brain is highly involved in motor control. Istradefylline...
Approved
Investigational
Matched Description: … [A184067] This region of the brain is highly involved in motor control. ... Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's …
Nesiritide
Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.
Approved
Investigational
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. It is a taurine conjugate of ursodeoxycholic acid with comparable therapeutic efficacy and safety, but a much higher hydrophilicity. Normally, hydrophilic bile acids regulates hydrophobic bile acids and...
Approved
Investigational
Matched Description: … the body's intake of dietary cholesterol and the body cholesterol content. ... [A249070] It is a taurine conjugate of [ursodeoxycholic acid] [A249065] with comparable therapeutic efficacy ... Tauroursodeoxycholic acid can reduce the absorption of cholesterol in the small intestine, thereby reducing …
Isopropyl myristate
Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer. At the moment the primary usage for which isopropyl myristate is formally indicated is as the active...
Approved
Experimental
Relatlimab
Relatlimab is a human IgG4 monoclonal antibody and novel immune checkpoint inhibitor that targets lymphocyte activation gene-3 (LAG-3).[A246165,L41265] It was the first commercially developed anti-LAG-3 antibody, entering clinical trials in 2013, and has garnered interest in the treatment of a variety of cancers, including leukemia and melanoma. As immune checkpoint...
Approved
Investigational
Matched Description: … a variety of cancers, including leukemia[A246160] and melanoma. ... inhibitor [nivolumab] in the combination product Opdualag (Bristol-Myers Squibb), for the treatment of ... anti-LAG-3 antibody, entering clinical trials in 2013,[A246155] and has garnered interest in the treatment of …
Tretinoin
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant,...
Approved
Investigational
Nutraceutical
Matched Description: … [A257474] It is an oxidation product in the physiological pathway of vitamin A metabolism. ... Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin …
Naloxone
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist,...
Approved
Vet approved
Matched Description: … within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. ... [L33724] Naloxone is indicated for the rapid reversal of these symptoms of central nervous system depression ... the opioid effect of buprenorphine. …
Ketotifen
Ketotifen is a benzocycloheptathiophene derivative with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine. Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis. In the...
Approved
Matched Description: … [A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of ... [L32283] In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various ... developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of …
Edoxaban
Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated...
Approved
Matched Description: … Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting ... (PE) following 5-10 days of initial therapy with a parenteral anticoagulant. ... It is indicated to reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular …
Carbamoylcholine
Carbamoylcholine, also known as carbachol, is a muscarinic agonist discovered in 1932. Carbamoylcholine was initially used as a treatment for migraines, induction of diuresis, and other parasympathetic effects.
Carbamoylcholine was granted FDA approval on 28 September 1972.
Approved
Matched Description: … [A226315] Carbamoylcholine was initially used as a treatment for migraines,[A226365] induction of diuresis …
Gatifloxacin
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as...
Approved
Investigational
Withdrawn
Matched Description: … Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. ... was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of ... The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due …
Iloprost
Iloprost is an analog of prostacyclin (PGI2; epoprostenol), an endogenous prostanoid mainly produced in the vascular endothelium. It is more stable than prostacyclin, which is short-lived. Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported...
Approved
Investigational
Matched Description: … [A263326] Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately ... Iloprost is an analog of prostacyclin (PGI2; epoprostenol), an endogenous prostanoid mainly produced …
Caplacizumab
Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU in October 2018 as a combination therapy...
Approved
Investigational
Matched Description: … Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of …
Fomivirsen
Fomivirsen is a antisense 21 mer phosphorothioate oligonucleotide. It is an antiviral agent that was used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. As a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human cytomegalovirus, it disrupts the...
Approved
Investigational
Withdrawn
Matched Description: … HAART dramatically reduced the number of cases of CMV. ... As a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human ... cytomegalovirus, it disrupts the replication of the virus through an antisense mechanism [L1428]. …
Trametinib
Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib...
Approved
Matched Description: … [A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. ... [L45583] Trametinib is currently approved to treat a variety of cancers with BRAF mutations, such as …
Brexanolone
As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like...
Approved
Investigational
Matched Description: … Since PPD, like various other types of depression, is characterized by feelings of sadness, worthlessness ... The development and availability of brexanolone for the treatment of PPD in adult females subsequently ... vs. placebo when added to standard-of-care [L5750]. …
Erdafitinib
In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing...
Approved
Investigational
Matched Description: … In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib ... that has progressed during or following platinum-containing chemotherapy, including within 12 months of ... genetic alterations for patients with metastatic bladder cancer, which demonstrates the development of …
Pexidartinib
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial...
Approved
Investigational
Matched Description: … significant functional limitations and a reduced quality of life in patients. ... [L7901] Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium ... [L7901]
While surgical resection is a current standard of care for tenosynovial giant cell tumor, …
Adapalene
Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with Cutibacterium acnes (also known as Propionibacterium acnes). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris. Adapalene has similar efficacy...
Approved
Matched Description: … , inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. ... Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris. ... Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production …
Clorazepic acid
Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.[A957,L44788] Following administration, clorazepate is rapidly converted to nordiazepam (N-desmethyldiazepam), its active metabolite, before entering systemic circulation. Similar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA)...
Approved
Illicit
Matched Description: … Also, the use of clorazepate exposes users to users to the risks of abuse, misuse, and addiction, and ... Similar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric ... water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of …
Mannitol
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a...
Approved
Investigational
Matched Description: … ; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function ... Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including ... On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of …
Belantamab mafodotin
Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufacturer began the process for withdrawal of the...
Approved
Matched Description: … multiple myeloma;[L15326] however, its manufacturer began the process for withdrawal of the US marketing ... A216756]
Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of …
Daunorubicin
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Approved
Matched Description: … anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of …
Activated charcoal
Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high...
Approved
Matched Description: … of carbonaceous organic matter. ... The clinical applications of activated charcoal occured in the early 1800's. ... Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion …
Displaying drugs 451 - 475 of 8039 in total