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Displaying drugs 451 - 475 of 797 in total

Oliceridine

Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid receptor subtype is predominantly targeted by and is responsible for...
Approved
Investigational
Matched Description: … [A218041] Oliceridine gained FDA approval on August 7, 2020, and is currently marketed by Trevena Inc ... Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal ... beneficial analgesic effects of opioids are coupled with severe adverse effects such as constipation and …

Margetuximab

The HER2 oncoprotein, the product of the human ERBB2/mouse neu genes, is a member of the HER family of receptor tyrosine kinases that includes the epidermal growth factor receptor (EGFR). Of the various subtypes of breast cancer, HER2-positive breast cancer is characterized by ERBB2 overexpression, a higher grade, a more...
Approved
Investigational
Matched Description: … A225751, A225756, A225766, A191829, L27986] Margextuximab was granted FDA approval on December 16, 2020 ... , and is currently marketed under the trademark MARGENZA™ by MacroGenics, Inc. ... breast cancer is characterized by _ERBB2_ overexpression, a higher grade, a more aggressive phenotype, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Vilanterol

Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug administration). Vilanterol was...
Approved
Matched Description: … TRELEGY ELLIPTA in September 2020. ... 5 years and older respectively. ... [A259961] Vilanterol is 1000 and 400 fold more selective for β2 than β1 and β3 adrenoceptors, respectively …
Matched Mixtures name: … Fluticasone Furoate and Vilanterol ... Fluticasone Furoate and Vilanterol …
Matched Categories: … vilanterol and fluticasone furoate ... vilanterol and umeclidinium bromide ... vilanterol, umeclidinium bromide and fluticasone furoate …

CIGB 2020 Vaccine

CIGB 2020 is a vaccine candidate administered nasally and sublingually, working to strengthen immunity in the areas administered. The vaccine was developed and tested by the Center for Genetic Engineering and Biotechnology (CIGB), in Havana Cuba. As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate...
Investigational
Matched Synonyms: … CIGB 2020 …
Matched Name: … CIGB 2020 Vaccine …
Matched Description: … CIGB 2020 is a vaccine candidate administered nasally and sublingually, working to strengthen immunity ... The vaccine was developed and tested by the Center for Genetic Engineering and Biotechnology (CIGB), ... As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate prophylaxis …

APR-2020

APR-2020 is a CD34+ cells that have been transduced in vitro with a lentiviral vector carrying a codon-optimized sequence for expressing the wild type RPS19 protein
Investigational
Matched Name: … APR-2020 …
Matched Description: … APR-2020 is a CD34+ cells that have been transduced in vitro with a lentiviral vector carrying a codon-optimized …

ENMD-981693

Investigational

TPIV 200

TPIV 200 is a vaccine consisting of proteins from the folate receptor alpha mixed with Granulocyte-macrophage colony-stimulating factor (GM-CSF).
Investigational

MTI-201

Investigational

G207

G207 is cancer-killing viruses, so-called oncolytic viruses, for the treatment of various forms of cancer developed by MediGene AG. These viruses are specific herpes simplex viruses, or HSVs, generally known as the cause of cold sores. MediGene uses these viruses, however, in a modified and "disarmed" form in order to...
Investigational
Matched Description: … MediGene uses these viruses, however, in a modified and "disarmed" form in order to make them utilizable …

Thallous cation Tl-201

Experimental

ABO-201

Investigational

PMX-205

Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …

EGT-201

EGT-201 is an adeno-associated viral vector serotype 9 (AAV9) vector-based gene therapy consisting of the alpha-N-acetyglucosaminidase (NAGLU) transgene. Developed by Esteve Pharmaceuticals, it is being investigated for Sanfilippo syndrome type B.
Investigational

Polysorbate 60

Experimental
Matched Synonyms: … Polysorbate 60 ... PEG-20 sorbitan palmitostearate ... Polyoxyethylene (20) sorbitan monostearate …
Matched Name: … Polysorbate 60 …

Rezatomidine

Rezatomidine has been used in trials studying the treatment of Fibromyalgia, Cystitis, Interstitial, Irritable Bowel Syndrome, and Diabetic Neuropathy, Painful.
Investigational
Matched Description: … in trials studying the treatment of Fibromyalgia, Cystitis, Interstitial, Irritable Bowel Syndrome, and …

Chitosan low molecular weight (20-200 mpa.s)

Experimental
Matched Synonyms: … Poliglusam low molecular weight (20-200 mpa.s) …
Matched Name: … Chitosan low molecular weight (20-200 mpa.s) …

Gildeuretinol

Investigational

Ezeprogind

Investigational

P-2045 Re-188

Investigational

Icotinib

Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc. was given a “May Proceed” from the US FDA to conduct a Phase I study for the...
Experimental
Investigational
Matched Description: … Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ( ... TKI) Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

3,20-Pregnanedione

Experimental

Namilumab

Namilumab has been used in trials studying the treatment of Plaque Psoriasis and Rheumatoid Arthritis.
Investigational
Matched Description: … Namilumab has been used in trials studying the treatment of Plaque Psoriasis and Rheumatoid Arthritis …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Fletikumab

Fletikumab is under investigation in clinical trial NCT01038674 (Safety and Tolerability of Anti-IL-20 in Subjects With Rheumatoid Arthritis).
Investigational
Matched Synonyms: … Anti-IL-20 …
Matched Description: … Fletikumab is under investigation in clinical trial NCT01038674 (Safety and Tolerability of Anti-IL-20 …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Thallium Tl-201

Thallium Tl-201 is under investigation in clinical trial NCT02697760 (The CZT Dynamic Myocardial Perfusion Imaging).
Investigational

Zamtocabtagene autoleucel

Investigational
Displaying drugs 451 - 475 of 797 in total