Displaying drugs 526 - 550 of 677 in total
RLYB212
RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia.
Investigational
Matched Synonyms: … Recombinant human IgG monoclonal HPA-1a antibody …
Matched Description: … It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia ... RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). …
Matched Description: … It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia ... RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). …
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
Experimental
Matched Name: … 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid …
2,3-Di-O-Sulfo-Alpha-D-Glucopyranose
Experimental
Matched Name: … 2,3-Di-O-Sulfo-Alpha-D-Glucopyranose …
Satralizumab
Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to tocilizumab, which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune inflammatory disorder of the central...
Approved
Matched Synonyms: … Humanised anti-IL-6 receptor monoclonal antibody …
Matched Description: … [A218551] It received subsequent approvals in Switzerland and Japan,[A218551] and was approved for use ... 6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on ... at least in part, by IL-6, including increased production of anti-aquaporin-4 (AQP4) autoantibodies and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … [A218551] It received subsequent approvals in Switzerland and Japan,[A218551] and was approved for use ... 6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on ... at least in part, by IL-6, including increased production of anti-aquaporin-4 (AQP4) autoantibodies and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
A166
A166 is an antibody-drug conjugate composed of a novel cytotoxic drug (Duo-5, anti-microtubule agent) site-specifically conjugated to an anti-HER2 antibody (trastuzumab) via a stable protease-cleavable valine citrulline linker.
Investigational
Matched Synonyms: … Recombinant humanized IgG1 anti-HER2 monoclonal antibody conjugated to Duostatin-5 …
Matched Description: … A166 is an antibody-drug conjugate composed of a novel cytotoxic drug (Duo-5, anti-microtubule agent) ... site-specifically conjugated to an anti-HER2 antibody (trastuzumab) via a stable protease-cleavable …
Matched Description: … A166 is an antibody-drug conjugate composed of a novel cytotoxic drug (Duo-5, anti-microtubule agent) ... site-specifically conjugated to an anti-HER2 antibody (trastuzumab) via a stable protease-cleavable …
Anetumab ravtansine
Anetumab ravtansine is under investigation in clinical trial NCT03455556 (Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer).
Investigational
Matched Synonyms: … Anti-mesothelin antibody-drug conjugate BAY 94-9343 …
Matched Description: … Anetumab ravtansine is under investigation in clinical trial NCT03455556 (Anetumab Ravtansine and Atezolizumab …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antibody-drug Conjugates …
Matched Description: … Anetumab ravtansine is under investigation in clinical trial NCT03455556 (Anetumab Ravtansine and Atezolizumab …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antibody-drug Conjugates …
CMG901
CMG901 is an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload.
Investigational
Matched Synonyms: … an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload …
Matched Description: … CMG901 is an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload. …
Matched Description: … CMG901 is an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload. …
Toralizumab
Toralizumab is under investigation in clinical trial NCT03605927 (CD40-L Blockade for Prevention of Acute Graft-versus-host Disease).
Investigational
Matched Synonyms: … Anti-CD 154 human-mouse monoclonal antibody …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Ordesekimab
Ordesekimab is under investigation in clinical trial NCT02633020 (Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Type II Refractory Celiac Disease).
Investigational
Matched Synonyms: … Human IgG1 anti-IL-15 monoclonal antibody …
Matched Description: … Ordesekimab is under investigation in clinical trial NCT02633020 (Study to Evaluate the Efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Ordesekimab is under investigation in clinical trial NCT02633020 (Study to Evaluate the Efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
AOC 1001
AOC 1001 is an antibody oligonucleotide conjugate (AOC), comprised of a human transferrin receptor 1 (TfR1) targeting, effector function null, humanized IgG1 antibody (AV01mAb) conjugated to one small interfering RNA (siRNA).
Investigational
Matched Synonyms: … an antibody oligonucleotide conjugate (AOC), comprised of a human transferrin receptor 1 (TfR1) targeting ... , effector function null, humanized IgG1 antibody (AV01mAb) conjugated to one small interfering RNA ( …
Matched Description: … AOC 1001 is an antibody oligonucleotide conjugate (AOC), comprised of a human transferrin receptor 1 ... (TfR1) targeting, effector function null, humanized IgG1 antibody (AV01mAb) conjugated to one small interfering …
Matched Description: … AOC 1001 is an antibody oligonucleotide conjugate (AOC), comprised of a human transferrin receptor 1 ... (TfR1) targeting, effector function null, humanized IgG1 antibody (AV01mAb) conjugated to one small interfering …
Sutimlimab
Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies directed against red blood cell surface antigens cause hemolysis at low (3-4°C) temperatures.[A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in the elderly.[A245159,L40114] In approximately 90% of cases,...
Approved
Investigational
Matched Synonyms: … Humanized IgG4 monoclonal antibody against total complement component 1, subcomponent s …
Matched Description: … Sutimlimab is a first-in-class humanized monoclonal antibody targeted at complement subunit C1s, which ... [A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in ... IgM) autoantibodies towards the I antigen on erythrocytes - these antibodies react optimally at 4°C and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … Sutimlimab is a first-in-class humanized monoclonal antibody targeted at complement subunit C1s, which ... [A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in ... IgM) autoantibodies towards the I antigen on erythrocytes - these antibodies react optimally at 4°C and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Carlumab
Carlumab has been used in trials studying the treatment of Cancer and Prostate Cancer.
Investigational
Withdrawn
Matched Synonyms: … Human monoclonal antibody targeting CC-chemokine ligand 2 (CNTO 888) …
Matched Description: … Carlumab has been used in trials studying the treatment of Cancer and Prostate Cancer. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Carlumab has been used in trials studying the treatment of Cancer and Prostate Cancer. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
OBI-999
Investigational
Matched Synonyms: … Humanized Anti-Globo H Monoclonal Antibody Monomethyl Auristatin E Conjugate …
6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
Experimental
Matched Name: … 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE …
Mirvetuximab soravtansine
Mirvetuximab soravtansine-gynx (IMGN853) is an antibody-drug conjugate (ADC) formed by a monoclonal antibody (M9346A) that targets folate receptor alpha (FRα), covalently joined by a cleavable disulfide linker to the genotoxic compound DM4 (also known as soravtansine or ravtansine).[A254392,L43967] DM4 is conjugated to the antibody with a drug-to-antibody ratio of 3.5:1....
Approved
Investigational
Matched Synonyms: … Anti-FOLR1-monoclonal-antibody-maytansinoid-conjugate-IMGN-853 …
Matched Description: … DM4 leads to cell-cycle arrest and apoptosis and is also able to diffuse into neighboring cells and induce ... [A254382] After an ADC/receptor complex is formed, mirvetuximab soravtansine-gynx is internalized, and ... the surface of epithelial tumor cells, characteristic of ovarian, endometrial, triple-negative breast and …
Matched Categories: … MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Antibody-drug Conjugates …
Matched Description: … DM4 leads to cell-cycle arrest and apoptosis and is also able to diffuse into neighboring cells and induce ... [A254382] After an ADC/receptor complex is formed, mirvetuximab soravtansine-gynx is internalized, and ... the surface of epithelial tumor cells, characteristic of ovarian, endometrial, triple-negative breast and …
Matched Categories: … MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Antibody-drug Conjugates …
Eluvixtamab
Investigational
Matched Synonyms: … A cd33/cd3 bispecific t-cell engager antibody for acute myeloid leukemia therapy …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
AD-114
Investigational
Matched Synonyms: … Human single domain antibody-like protein inhibitor of the chemokine receptor type 4 …
Sucralfate
Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a cytoprotective agent, protecting cells in...
Approved
Matched Synonyms: … Hexadeca-μ-hydroxytetracosahydroxy[μ8-[1,3,4,6-tetra-O-sulfo-β-Dfructofuranosyl-α-D-glucopyranoside tetrakis …
Matched Description: … It is sold under many brands and is available in both tablet and suspension forms. ... Sucralfate has been shown to be a well-tolerated and safe drug. ... Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal …
Matched Categories: … Alimentary Tract and Metabolism ... Sulfur Compounds ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Matched Description: … It is sold under many brands and is available in both tablet and suspension forms. ... Sucralfate has been shown to be a well-tolerated and safe drug. ... Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal …
Matched Categories: … Alimentary Tract and Metabolism ... Sulfur Compounds ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Rivabazumab pegol
Rivabazumab pegol is being investigated as a treatment of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis.
Investigational
Matched Synonyms: … PEGylated recombinant anti-Pseudomonas aeruginosa PcrV Fab' antibody ... KB001-A (AN ANTI-PCRV PEGYLATED MONOCLONAL ANTIBODY FRAGMENT TO THE TYPE III SECRETION SYSTEM OF PSEUDOMONAS ... ANTI-PSEUDOMONAS AERUGINOSA TYPE III SECRETION SYSTEM (TTSS)PCRV PROTEIN, PEGYLATED HUMANIZED MONOCLONAL ANTIBODY …
Etavopivat
Etavopivat is a small molecule activator of erythrocyte pyruvate kinase (PKR) under investigation for the treatment of sickle cell disease.
Investigational
Matched Synonyms: … 1-propanone, 1-(5-((2,3-dihydro-1,4-dioxino(2,3-b)pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo(3,4 …
Matched Iupac: … (2S)-1-(5-{2H,3H-[1,4]dioxino[2,3-b]pyridine-7-sulfonyl}-1H,2H,3H,4H,5H,6H-pyrrolo[3,4-c]pyrrol-2-yl) …
Matched Description: … Etavopivat is a small molecule activator of erythrocyte pyruvate kinase (PKR) under investigation for …
Matched Iupac: … (2S)-1-(5-{2H,3H-[1,4]dioxino[2,3-b]pyridine-7-sulfonyl}-1H,2H,3H,4H,5H,6H-pyrrolo[3,4-c]pyrrol-2-yl) …
Matched Description: … Etavopivat is a small molecule activator of erythrocyte pyruvate kinase (PKR) under investigation for …
DSM-265
DSM265 has been used in trials studying the prevention and treatment of Malaria.
Investigational
Matched Synonyms: … Sulfur, (4-((2-(1,1-difluoroethyl)-5-methyl(1,2,4)triazolo(1,5-a)pyrimidin-7-yl)amino)phenyl)pentafluoro …
Matched Description: … DSM265 has been used in trials studying the prevention and treatment of Malaria. …
Matched Description: … DSM265 has been used in trials studying the prevention and treatment of Malaria. …
5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
Experimental
Matched Name: … 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE …
Displaying drugs 526 - 550 of 677 in total