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Displaying drugs 676 - 700 of 918 in total

Vericiguat

Vericiguat is a direct stimulator of soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and hospitalizations. A key component of the NO-sGC-cGMP signaling pathway that helps to regulate the cardiovascular system, sGC enzymes are intracellular enzymes found in vascular smooth muscle cells (amongst...
Approved
Investigational
Matched Description: … soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and ... messenger, activating a number of downstream signaling cascades that elicit a broad variety of effects, and ... thereby helps to prevent the myocardial and vascular dysfunction associated with decreased sGC activity …
Matched Products: … VERQUVO FILM-COATED TABLET 2.5MG ... VERQUVO FILM-COATED TABLET 10MG ... VERQUVO FILM-COATED TABLET 5MG …

Trimetazidine

Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. Trimetazidine has been studied as a treatment for angina pectoris since the late 1960s.[A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response...
Approved
Investigational
Matched Description: … to myocardial ischemia, activate sodium-hydrogen and sodium-calcium antiport systems. ... [A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response …
Matched Products: … SITOREL MR 35 MG DEĞIŞTIRILMIŞ SALIMLI FILM TABLET,FILM TABLET, 60 ADET ... SITOREL 20 MG FILM TABLET, 60 ADET ... VASOFIX 20 MG FILM TABLET, 60 ADET …

Sevelamer

Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Approved
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Matched Products: … SEVYAR 800 MG FILM KAPLI TABLET , 90 FILM KAPLI TABLET ... SEVELA FILM COATED TABLET 800MG ... RENADIN 800 MG FILM TABLET, 180 ADET …

Desogestrel

Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological...
Approved
Matched Description: … family which was largely used in Europe before being approved in the US and Canada. ... Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane ... [A176339] It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent …
Matched Mixtures name: … Desogestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Desogestrel and Ethinyl Estradiol ... Desogestrel and Ethinyl Estradiol and Ethinyl Estradiol …
Matched Categories: … desogestrel and estrogen ... Combination Contraceptives (with Estrogen and derivatives) ... Genito Urinary System and Sex Hormones ... desogestrel and ethinylestradiol ... desogestrel and ethinylestradiol …
Matched Products: … Desirett 75mcg film-coated tablet ... Azalia 0.075 mg film-coated tablet ... DESIRETT 75 MCG FILM KAPLI TABLET ,28 ADET …

Risperidone

Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and...
Approved
Investigational
Matched Description: … D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical ... mental health conditions including schizophrenia and bipolar disorder. ... Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and …
Matched Products: … RISPERIDON - CT 0.5MG FILM ... WELRIS 1 MG FİLM TABLET, 30 ADET ... WELRIS 1 MG FİLM TABLET, 60 ADET …

Linagliptin

Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding . Linagliptin was approved by...
Approved
Matched Description: … that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and …
Matched Mixtures name: … Glyxambi Film-Coated Tablets 25mg/5mg ... Glyxambi Film-Coated Tablets 10mg/5mg ... GLYXAMBI FILM-COATED TABLETS 25 MG/5 MG …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and linagliptin ... linagliptin and empagliflozin ... metformin, linagliptin and empagliflozin ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … TRAJENTA 5MG FILM-COATED TABLETS ... SNOXX 5 MG FİLM KAPLI TABLET ... TRAJENTA 5 MG FILM KAPLI TABLET …

Dacomitinib

Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on...
Approved
Investigational
Matched Description: … [A40009] Dacomitinib was developed by Pfizer Inc and approved by the FDA on September 27, 2018. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Vizimpro 30 mg Film-Coated Tablets ... Vizimpro 15 mg Film-Coated Tablets ... VIZIMPRO FILM-COATED TABLET 15MG …

Roxadustat

Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels. Roxadustat was first approved...
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Matched Products: … EVRENZO 20 MG FİLM KAPLI TABLET, 12 ADET ... EVRENZO 50 MG FİLM KAPLI TABLET, 12 ADET ... EVRENZO 70 MG FİLM KAPLI TABLET, 12 ADET …

Lurasidone

Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently …
Matched Products: … LEDASON 60 MG FİLM KAPLI TABLET, 30 ADET ... LEDASON 120 MG FİLM KAPLI TABLET, 30 ADET ... LUİGON 20 MG FİLM KAPLI TABLET, 30 ADET …

Mirabegron

Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as solifenacin and darifenacin, it lacks significant antimuscarinic activity, which is...
Approved
Matched Description: … receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and ... amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and ... a comparatively favorable adverse effect profile as compared to other available treatment options, and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence …
Matched Products: … BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , 10 TABLET ... BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , 100 TABLET ... BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , 50 TABLET …

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated ... [L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no ... choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and …
Matched Products: … KEPPRA 500MG FILM COATED TABLET ... KEPPRA 1000MG FILM COATED TABLET ... Epivon film-coated tablets 250mg …

Deferiprone

Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired....
Approved
Matched Products: … FERRIPROX FILM-COATED TABLET 500 mg ... Ferriprox 1000mg Film-Coated Tablet ... HİERO 500 MG FİLM KAPLI TABLET, 100 ADET …

Letermovir

Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors. Letermovir has recieved both priority and orphan drug status...
Approved
Investigational
Matched Description: … [A31290] Letermovir has recieved both priority and orphan drug status from the FDA. …
Matched Products: … PREVYMIS 240MG FILM-COATED TABLET ... PREVYMIS 480MG FILM-COATED TABLET ... PREVYMIS FILM COATED TABLET 240MG …

Baloxavir marboxil

Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Categories: … Baloxavir and prodrugs …
Matched Products: … XOFLUZA FILM-COATED TABLET 20MG ... XOFLUZA FILM-COATED TABLET 40MG ... XOFLUZA FILM COATED TABLETS 20MG …

Tenofovir alafenamide

Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and ... [L4388,L9010] Tenofovir alafenamide was developed by Gilead Sciences Inc and granted FDA approval ... alafenamide is indicated to treat chronic hepatitis B,[L6241] treat HIV-1,[L4388,L6277,L6280,L6283] and …
Matched Mixtures name: … DESCOVY FILM COATED TABLET 200 MG/25 MG ... DESCOVY FILM COATED TABLET 200 MG/10 MG ... ODEFSEY FILM-COATED TABLET 200MG/25MG/25MG …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Tenofovir and prodrugs ... emtricitabine and tenofovir alafenamide ... emtricitabine, tenofovir alafenamide and rilpivirine ... emtricitabine, tenofovir alafenamide and bictegravir …
Matched Products: … VEMLIDY FILM COATED TABLET 25 MG ... VEMLİDY 25 MG FİLM KAPLI TABLET, 30 ADET ... VEMLİDY 25 MG FİLM KAPLI TABLET, 90 ADET …

Alpelisib

Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target...
Approved
Investigational
Matched Description: … children who require systemic therapy. ... Alpelisib is marketed under the trade name Piqray and is available as oral tablets. ... that plays a role in various biological processes, including proliferation, survival, differentiation, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Trezilent 50mg Film-Coated Tablets ... Trezilent 200mg Film-Coated Tablets ... Trezilent 150mg Film-Coated Tablets …

Gabapentin

Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic...
Approved
Investigational
Matched Description: … It is structurally and functionally related to another GABA derivative, [pregabalin]. ... other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Gabapentin and Prodrugs …
Matched Products: … GEMUDA 100 MG FILM TABLET , FILM TABLET, 20 ADET ... GEMUDA 300 MG FILM TABLET , FILM TABLET, 50 ADET ... GEMUDA 400 MG FILM TABLET , FILM TABLET, 50 ADET …

Lipoic acid

A vitamin-like antioxidant.
Approved
Investigational
Nutraceutical
Matched Mixtures name: … PIONAL 15/500/300 MG FILM TABLET, 60 ADET ... PIONAL 15/500/300 MG FILM TABLET, 90 ADET ... PIONAL 15/850/300 MG FILM TABLET, 60 ADET …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes ... Various Alimentary Tract and Metabolism Products …
Matched Products: … ALATAB 600 MG FİLM TABLET, 30 ADET ... ALFAZAN 600 MG FİLM TABLET, 30 ADET ... TIOPATI 600 MG FILM TABLET, 30 ADET …

Deferasirox

Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Approved
Investigational
Matched Description: … Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload …
Matched Products: … JADENU FILM COATED TABLET 90MG ... JADENU FILM COATED TABLET 180MG ... JADENU FILM COATED TABLET 360MG …

Daclatasvir

Daclatasvir is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. It is marketed under the name DAKLINZA and is contained in daily oral tablets as the hydrochloride salt form . Hepatitis C is an infectious liver disease...
Approved
Investigational
Matched Description: … Combination therapies that include daclatasir can be used for challenging-to-treat patients who have ... daclatasvir and [DB08934] therapy were 88% and 99%, respectively [FDA Label]. ... Daclatasvir is shown to target both the cis- and trans-acting functions of NS5A and disrupts the function …
Matched Categories: … Amino Acids, Peptides, and Proteins ... daclatasvir, asunaprevir and beclabuvir …
Matched Products: … DAKLINZA 30 MG FILM KAPLI TABLET ,FILM KAPLI TABLET, 28 ADET ... DAKLINZA 60 MG FILM KAPLI TABLET ,FILM KAPLI TABLET, 28 ADET ... Daclavir 60mg Film Coated Tablet …

Ribociclib

Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play...
Approved
Investigational
Matched Description: … These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. ... that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … KISQALI FILM-COATED TABLET 200MG ... Kryxana 200mg Film-coated Tablets ... VALAMOR 200 MG FİLM KAPLI TABLET, 63 ADET …

Lercanidipine

Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Approved
Investigational
Matched Mixtures name: … ZANITEK 10 MG/10MG FILM TABLET,90 ADET ... ZANITEK 10 MG/10MG FILM TABLET, 30 ADET ... ZANITEK 20 MG/10MG FILM TABLET, 30 ADET …
Matched Categories: … ACE Inhibitors and Calcium Channel Blockers ... Calcium-Regulating Hormones and Agents ... valsartan and lercanidipine ... enalapril and lercanidipine ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …
Matched Products: … ZANIDIP 10MG FILM COATED TABLETS ... Zanidip 20mg, film-coated tablet ... LERCADIP 10 MG FILM TABLET, 30 ADET …

Bosutinib

Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor,...
Approved
Matched Description: … Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine ... BCR-ABL inhibitors like bosutinib inhibit most resistance-conferring BCR-ABL mutations except V299L and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … BOSULİF 500 MG FİLM KAPLI TABLET, 28 ADET ... BOSULİF 500 MG FİLM KAPLI TABLET, 30 ADET ... BOSULİF 100 MG FİLM KAPLI TABLET, 28 ADET …

Capmatinib

Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or overexpression - is known to occur in many...
Approved
Investigational
Matched Description: … approval by the FDA on May 6, 2020,[L13380] for the treatment of NSCLC in patients whose tumors have ... such as STAT3, PI3K/ATK, and RAS/MAPK. ... tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … TABRECTA FILM-COATED TABLET 150mg ... Rahika 150mg Film-coated Tablet ... TABRECTA FILM-COATED TABLET 200mg …

Rilpivirine

Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potency and reduces the chance of resistance...
Approved
Matched Description: … [A31331] Rilpivirine was developed by Tilbotec, Inc. and FDA approved on May 20, 2011. ... [A31329] The internal conformational flexibility of rilpivirine and the plasticity of it interacting ... binding site gives it a very high potency and reduces the chance of resistance compared to other NNRTI's …
Matched Mixtures name: … COMPLERA FILM-COATED TABLET 200MG/25MG/300MG ... ODEFSEY 200 MG/25 MG/25 MG FİLM KAPLI TABLET, 90 ADET ... ODEFSEY 200 MG/25 MG/25 MG FİLM KAPLI TABLET, 30 ADET …
Matched Categories: … dolutegravir and rilpivirine ... emtricitabine, tenofovir disoproxil and rilpivirine ... emtricitabine, tenofovir alafenamide and rilpivirine …
Matched Products: … EDURANT FILM-COATED TABLET 25 MG ... Edurant 25mg film-coated tablet ... EDURANT 25 MG FILM KAPLI TABLET, 30 ADET …
Displaying drugs 676 - 700 of 918 in total