Displaying drugs 751 - 775 of 1247 in total
Efzofitimod
Efzofitimod (ATYR1923) is a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody. It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states.
Investigational
Matched Synonyms: … Human IgG1Fc- iMod domain (amino acids 2-60) of human HARS fusion protein …
Matched Description: … It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response ... protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human …
Matched Description: … It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response ... protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human …
Gebasaxturev
Investigational
Matched Synonyms: … Human coxsackievirus A21 ... Enterovirus human enterovirus C serogroup coxsackievirus serotype A21 …
Bertilimumab
Bertilimumab is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic disorders, has moved into pre-clinical development. It is developed by MedImmune for the treatment of Allergic Rhinitis.
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4, ANTI-(HUMAN EOTAXIN 1) (HUMAN MONOCLONAL CAT-213 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN …
Matched Description: … Bertilimumab is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic …
Matched Description: … Bertilimumab is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic …
Nipocalimab
Nipocalimab is under investigation in clinical trial NCT04119050 (Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia).
Investigational
Matched Synonyms: … Immunoglobulin g1, anti-(human neonatal fc receptor) (human monoclonal m281 .gamma.-1 chain), disulfide ... with human monoclonal m281 .lambda. …
Matched Description: … Nipocalimab is under investigation in clinical trial NCT04119050 (Efficacy and Safety of M281 in Adults …
Matched Description: … Nipocalimab is under investigation in clinical trial NCT04119050 (Efficacy and Safety of M281 in Adults …
Lemzoparlimab
Lemzoparlimab is under investigation in clinical trial NCT04912063 (Study to Evaluate Adverse Events and Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax in Participants With Myelodysplastic Syndrome).
Investigational
Matched Synonyms: … Immunoglobulin g4(228-proline), anti-(human cd47 antigen) (human monoclonal tj011133 .gamma.4-chain), ... disulfide with human monoclonal tj011133 .kappa. …
Matched Description: … Lemzoparlimab is under investigation in clinical trial NCT04912063 (Study to Evaluate Adverse Events and ... Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and ... Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax …
Matched Description: … Lemzoparlimab is under investigation in clinical trial NCT04912063 (Study to Evaluate Adverse Events and ... Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and ... Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax …
Xeligekimab
Xeligekimab is under investigation in clinical trial NCT06028490 (A Study of Il4rα Monoclonal Antibody in Patients With Uncontrolled Seasonal Allergic Rhinitis.).
Investigational
Matched Synonyms: … Immunoglobulin g4 (235-proline), anti-(human interleukin 17a) (human monoclonal gr1501 .gamma.4-chain ... ), disulfide with human monoclonal gr1501 .kappa. …
Recombinant human palmitoyl-protein thioesterase-1
Investigational
Matched Synonyms: … Recombinant human palmitoyl-protein thioeserase-1 ... RECOMBINANT HUMAN PALMITOYL-PROTEIN THIOESERASE-1 (RHPPT1) …
Matched Name: … Recombinant human palmitoyl-protein thioesterase-1 …
Matched Name: … Recombinant human palmitoyl-protein thioesterase-1 …
Retlirafusp alfa
Investigational
Matched Synonyms: … peptide linker ((ggggs)4g) fusion protein with 20-136-type II transforming growth factor .beta. receptor ... (human isoform 1), disulfide with (85-glutamic acid) human-mus musculus monoclonal SHR-1316 .kappa. ... programmed death-ligand 1) (human-mus musculus monoclonal SHR-1316 .gamma.4-chain) fusion protein with …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Atibuclimab
Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis.
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4, ANTI-(HUMAN CD14 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL IC14 .GAMMA.4-CHAIN), DISULFIDE ... IC14, (RECOMBINANT CHIMERIC MAB AGAINST HUMAN CD14) ... WITH HUMAN-MUS MUSCULUS MONOCLONAL IC14 .KAPPA. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Befovacimab
Investigational
Matched Synonyms: … Immunoglobulin g2, anti-(human tissue factor pathway inhibitor) (human monoclonal 1093884 .gamma.2-chain ... ), disulfide with human monoclonal 1093884 .lambda. ... Human tissue factor pathway inhibitor-neutralizing antibody (bay 1093884) …
Teprotumumab
Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by the FDA...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human monoclonal heavy chain), ... disulfide with human monoclonal light chain, dimer …
Matched Description: … disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016[A190129] and ... Thyroid eye disease is a potentially debilitating complication of Graves' Disease involving inflammation and ... tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016[A190129] and ... Thyroid eye disease is a potentially debilitating complication of Graves' Disease involving inflammation and ... tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Interleukin-7
Interleukin 7 has been used in trials studying the treatment of Metastatic Breast Cancer.
Investigational
Matched Synonyms: … Interleukin-7 human recombinant ... Recombinant human interleukin-7 ... Glycosylated recombinant human interleukin-7 …
Matched Description: … Interleukin 7 has been used in trials studying the treatment of Metastatic Breast Cancer. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Matched Description: … Interleukin 7 has been used in trials studying the treatment of Metastatic Breast Cancer. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Osemitamab
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G1, ANTI-(HUMAN CLAUDIN 18.2) (HUMAN-MUS MUSCULUS MONOCLONAL TST001 .GAMMA.1-CHAIN), DISULFIDE ... WITH HUMAN-MUS MUSCULUS MONOCLONAL TST001 .KAPPA. …
Pulocimab
Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma).
Investigational
Matched Synonyms: … Immunoglobulin g1, anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ak109 ... .gamma.1-chain), disulfide with human monoclonal ak109 .kappa. …
Matched Description: … Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and …
Matched Description: … Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and …
Metoprolol
Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative. To this date,...
Approved
Investigational
Matched Description: … Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives ... widely prescribed in the Netherlands, New Zealand, and the US. ... [T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is …
Matched Mixtures name: … Metoprolol Tartrate and Hydrochlorothiazide ... Metoprolol Tartrate and Hydrochlorothiazide ... Metoprolol Tartrate and Hydrochlorothiazide …
Matched Categories: … Beta Blocking Agents and Thiazides ... Beta blocking agents and calcium channel blockers ... Beta Blocking Agents, Selective, and Thiazides ... metoprolol and felodipine ... metoprolol and ivabradine …
Matched Products: … Truemed Group LLC ... Q-metoprolol (type L) ... Nu-metoprolol (type L) …
Matched Mixtures name: … Metoprolol Tartrate and Hydrochlorothiazide ... Metoprolol Tartrate and Hydrochlorothiazide ... Metoprolol Tartrate and Hydrochlorothiazide …
Matched Categories: … Beta Blocking Agents and Thiazides ... Beta blocking agents and calcium channel blockers ... Beta Blocking Agents, Selective, and Thiazides ... metoprolol and felodipine ... metoprolol and ivabradine …
Matched Products: … Truemed Group LLC ... Q-metoprolol (type L) ... Nu-metoprolol (type L) …
Rinucumab
Rinucumab is under investigation in clinical trial NCT02418754 (Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-related Macular Degeneration (AMD)).
Investigational
Matched Synonyms: … Immunoglobulin g4, anti-(human platelet-derived growth factor receptor~) (human monoclonal regn2176 heavy ... chain), disulfide with human monoclonal regn2176 k-chain, dimer …
Itepekimab
Itepekimab is under investigation in clinical trial NCT03546907 (Proof-of-concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-il-33 Mab) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)).
Investigational
Matched Synonyms: … Immunoglobulin igg4 (230-proline), anti-(human interleukin 33) (human monoclonal regn3500 .gamma.4-chain ... ), disulfide with human monoclonal regn3500 .kappa. …
Matched Description: … investigation in clinical trial NCT03546907 (Proof-of-concept Study to Assess the Efficacy, Safety and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … investigation in clinical trial NCT03546907 (Proof-of-concept Study to Assess the Efficacy, Safety and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Peresolimab
Peresolimab is under investigation in clinical trial NCT04634253 (A Study of LY3462817 in Participants With Rheumatoid Arthritis).
Investigational
Matched Synonyms: … Immunoglobulin g1, anti-(human programmed cell death protein 1) (human monoclonal ly3462817 .gamma.1- ... chain), disulfide with human monoclonal ly3462817 .kappa. …
Velafermin
Velafermin was a novel investigational protein therapeutic, also known as fibroblast growth factor-20 (FGF-20), which promotes both epithelial and mesenchymal cell proliferation in vitro and has demonstrated activity in multiple animal models. Velafermin was investigated as a potential therapy for the prevention and treatment of oral mucositis by fostering the...
Investigational
Matched Synonyms: … RECOMBINANT HUMAN FIBROBLAST GROWTH FACTOR-20 ... FIBROBLAST GROWTH FACTOR 20 (HUMAN RECOMBINANT CG53135) …
Matched Description: … protein therapeutic, also known as fibroblast growth factor-20 (FGF-20), which promotes both epithelial and ... mesenchymal cell proliferation in vitro and has demonstrated activity in multiple animal models. ... by fostering the regeneration and repair of the cells lining the gastrointestinal tract. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Matched Description: … protein therapeutic, also known as fibroblast growth factor-20 (FGF-20), which promotes both epithelial and ... mesenchymal cell proliferation in vitro and has demonstrated activity in multiple animal models. ... by fostering the regeneration and repair of the cells lining the gastrointestinal tract. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Conestat alfa
C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within...
Approved
Investigational
Matched Synonyms: … Recombinant human C1-INH ... Recombinant human C1 inhibitor ... Recombinant human C1-inhibitor …
Matched Description: … , and tPA and plasmin within the fibrinolytic pathway. ... The primary function of endogenous C1INH is to regulate the activation of the complement and contact ... of several target proteases within these pathways including activated C1s, kallikrein, factor XIIa and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Matched Description: … , and tPA and plasmin within the fibrinolytic pathway. ... The primary function of endogenous C1INH is to regulate the activation of the complement and contact ... of several target proteases within these pathways including activated C1s, kallikrein, factor XIIa and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Lecanemab
Lecanemab is a recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta (Aβ), which are implicated in the pathophysiology of Alzheimer’s disease. Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952] with high selectivity to Aβ...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human beta-amyloid protofibril) (human-mus musculus monoclonal BAN2401 heavy ... chain), disulfide with human-mus musculus monoclonal BAN2401 light chain, dimer …
Matched Description: … recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and ... [L44537] Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and ... [L44537] Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Mirvetuximab
Investigational
Matched Synonyms: … (human-mus musculus monoclonal m9346a heavy chain), disulfide with human-mus musculus monoclonal m9346a ... Immunoglobulin g1, anti-(human folate receptor .alpha.) …
Zolbetuximab
Zolbetuximab is under investigation in clinical trial NCT01630083 (Efficacy and Safety of IMAB362 in Combination With the EOX Regimen for CLDN18.2-positive Gastric Cancer).
Investigational
Matched Synonyms: … immunoglobulin G1, anti-(human Claudin-18.2) (human-mus musculus monoclonal IMAB362 heavy chain), disulfide ... with human-mus musculus monoclonal IMAB362 .kappa. …
Matched Description: … Zolbetuximab is under investigation in clinical trial NCT01630083 (Efficacy and Safety of IMAB362 in …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Zolbetuximab is under investigation in clinical trial NCT01630083 (Efficacy and Safety of IMAB362 in …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Human Umbilical Cord Mesenchymal Stem Cells
Stem cells obtained from amniotic fluid, the umbilical cord (UC), and placenta are gaining in popularity. Stem cells from the umbilical cord offer several advantages, including: non-invasive collection procedures, more hearty and steady growth than bone-marrow derived stem cells (they can maintain a steady doubling time (DT) over up to...
Investigational
Matched Synonyms: … Human Umbilical Cord Wharton’s Jelly-derived Mesenchymal Stem Cells …
Matched Name: … Human Umbilical Cord Mesenchymal Stem Cells …
Matched Description: … cells are extracted by either the explant or the enzymatic digestion method, though neither method has been ... Stem cells obtained from amniotic fluid, the umbilical cord (UC), and placenta are gaining in popularity ... class II and its co-stimulatory ligands like CD40, CD80, and CD86. …
Matched Name: … Human Umbilical Cord Mesenchymal Stem Cells …
Matched Description: … cells are extracted by either the explant or the enzymatic digestion method, though neither method has been ... Stem cells obtained from amniotic fluid, the umbilical cord (UC), and placenta are gaining in popularity ... class II and its co-stimulatory ligands like CD40, CD80, and CD86. …
Human cord blood hematopoietic progenitor cell
Human cord blood hematopoietic progenitor cells consist of hematopoietic progenitor cells, monocytes, lymphocytes, and granulocytes from human cord blood. They are used during allogeneic unrelated and related hematopoietic stem cell transplantation procedures in patients with disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment. Human...
Approved
Matched Name: … Human cord blood hematopoietic progenitor cell …
Matched Description: … lymphocytes, and granulocytes from human cord blood. ... Human umbilical cord is a rich source of hematopoietic stem cells and progenitor cells that are capable ... marrow transplantation; it allows shorter time to transplant and tolerance of 1–2 human leukocyte antigen …
Matched Description: … lymphocytes, and granulocytes from human cord blood. ... Human umbilical cord is a rich source of hematopoietic stem cells and progenitor cells that are capable ... marrow transplantation; it allows shorter time to transplant and tolerance of 1–2 human leukocyte antigen …
Displaying drugs 751 - 775 of 1247 in total