Displaying drugs 8726 - 8750 of 9333 in total
Tesmilifene
Tesmilifene is a novel potentiator of chemotherapy which, when added to doxorubicin, achieved an unexpected and very large survival advantage over doxorubicin alone in a randomized trial in advanced breast cancer.
Investigational
Matched Synonyms: … N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine …
Matched Iupac: … [2-(4-benzylphenoxy)ethyl]diethylamine …
Matched Iupac: … [2-(4-benzylphenoxy)ethyl]diethylamine …
CTx-PDE6b
CTx-PDE6b is an adeno-associated virus (AAV) based gene therapy designed to deliver a full-length non-mutated copy of the functional human PDE6b gene. Being commercialied by Coave Therapeutics, it is being investigated for the treatment of retinitis pigmentosa due to PDE6b gene mutations.
Investigational
2-(Thiomethylene)-4-Methylpentanoic Acid
Experimental
Matched Name: … 2-(Thiomethylene)-4-Methylpentanoic Acid …
Matched Iupac: … (2S)-4-methyl-2-(sulfanylmethyl)pentanoic acid …
Matched Iupac: … (2S)-4-methyl-2-(sulfanylmethyl)pentanoic acid …
4-Iodobenzo[B]Thiophene-2-Carboxamidine
Experimental
Matched Name: … 4-Iodobenzo[B]Thiophene-2-Carboxamidine …
Matched Iupac: … [amino(4-iodo-1-benzothiophen-2-yl)methylidene]azanium …
Matched Iupac: … [amino(4-iodo-1-benzothiophen-2-yl)methylidene]azanium …
5-Mercaptoethanol-2-decenoyl-coenzyme A
Experimental
Matched Name: … 5-Mercaptoethanol-2-decenoyl-coenzyme A …
Matched Iupac: … 6-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-({[hydroxy({hydroxy[(4R)-4-hydroxy-2,2-dimethyl-3-oxo-4-({2-[(2- ... {[(2E,5S)-5-[(2-oxoethyl)sulfanyl]dec-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}amino)butoxy]phosphoryl} ... oxy)phosphoryl]oxy}methyl)-4-(phosphonooxy)oxolan-2-yl]-7H-9lambda5-purin-9-ylium …
Matched Iupac: … 6-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-({[hydroxy({hydroxy[(4R)-4-hydroxy-2,2-dimethyl-3-oxo-4-({2-[(2- ... {[(2E,5S)-5-[(2-oxoethyl)sulfanyl]dec-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}amino)butoxy]phosphoryl} ... oxy)phosphoryl]oxy}methyl)-4-(phosphonooxy)oxolan-2-yl]-7H-9lambda5-purin-9-ylium …
GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE
Experimental
Matched Name: … GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE …
Matched Iupac: … 3,4-d][1,3]dioxol-2-yl]phosphonic acid ... [(2S,3aR,4R,6R,6aR)-4-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-6-(hydroxymethyl)-tetrahydro-2H-furo[ …
Matched Iupac: … 3,4-d][1,3]dioxol-2-yl]phosphonic acid ... [(2S,3aR,4R,6R,6aR)-4-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-6-(hydroxymethyl)-tetrahydro-2H-furo[ …
5-methyl-6-phenylquinazoline-2,4-diamine
Experimental
Buformin
Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis.
Investigational
Withdrawn
Matched Synonyms: … 1-Butylbiguanide …
Sodium dichloroacetate
Investigational
Binodenoson
Binodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A2A receptor. This specificity allows Binodenoson to deliver - in a single injection - a more effective dose of medication with fewer side effects than current treatments, which typically require a...
Investigational
Matched Synonyms: … 2-((Cyclohexylmethylene)hydrazino)adenosine …
Matched Iupac: … (2R,3R,4S,5R)-2-{6-amino-2-[(2E)-2-(cyclohexylmethylidene)hydrazin-1-yl]-9H-purin-9-yl}-5-(hydroxymethyl …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (2R,3R,4S,5R)-2-{6-amino-2-[(2E)-2-(cyclohexylmethylidene)hydrazin-1-yl]-9H-purin-9-yl}-5-(hydroxymethyl …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide
Experimental
Matched Name: … Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide …
Matched Iupac: … (2R)-N-[(1E,3R)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]-4-methyl-2-{[(E)-morpholine-4-carbonyl]amino …
Matched Iupac: … (2R)-N-[(1E,3R)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]-4-methyl-2-{[(E)-morpholine-4-carbonyl]amino …
Tetrafluoroborate
Tetrafluoroborate is under investigation in clinical trial NCT02907073 (Positron Emission Tomography (PET) Imaging Studies With NIS Reporter).
Investigational
Matched Synonyms: … Borate(1-), tetrafluoro- ... Tetrafluoroborate(1-) …
1,3-bis-([3-[3-[3-(4-{3-[3-nitro-5-(galactopyranosyloxy)-benzoylamino]-propyl}-piperazin-1-yl)-propylamino-3,4-dioxo-cyclobutenyl]-amino-propoxy-ethoxy-ethoxy]-propyl-]amino-carbonyloxy)-2-amino-propane
Experimental
Matched Name: … -3,4-dioxo-cyclobutenyl]-amino-propoxy-ethoxy-ethoxy]-propyl-]amino-carbonyloxy)-2-amino-propane ... 1,3-bis-([3-[3-[3-(4-{3-[3-nitro-5-(galactopyranosyloxy)-benzoylamino]-propyl}-piperazin-1-yl)-propylamino …
Matched Iupac: … (Z)-N-[3-(4-{3-[(2-{14-[(E)-[(2-amino-3-{[(E)-{3-[2-(2-{3-[(2-{[3-(4-{3-[(Z)-[hydroxy(3-nitro-5-{[(2R ... -yl)amino]propyl}piperazin-1-yl)propyl]-3-nitro-5-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}benzene ... ]oxy}propoxy)(hydroxy)methylidene]amino]-5,8,11-trioxa-1-azatetradecan-1-yl}-3,4-dioxocyclobut-1-en-1 ... -1-yl)propyl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]propoxy}ethoxy)ethoxy]propyl}-C-hydroxycarbonimidoyl ... -1-carboximidic acid …
Matched Iupac: … (Z)-N-[3-(4-{3-[(2-{14-[(E)-[(2-amino-3-{[(E)-{3-[2-(2-{3-[(2-{[3-(4-{3-[(Z)-[hydroxy(3-nitro-5-{[(2R ... -yl)amino]propyl}piperazin-1-yl)propyl]-3-nitro-5-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}benzene ... ]oxy}propoxy)(hydroxy)methylidene]amino]-5,8,11-trioxa-1-azatetradecan-1-yl}-3,4-dioxocyclobut-1-en-1 ... -1-yl)propyl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]propoxy}ethoxy)ethoxy]propyl}-C-hydroxycarbonimidoyl ... -1-carboximidic acid …
5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione
Experimental
D-naphthyl-1-acetamido boronic acid alanine
Experimental
Matched Name: … D-naphthyl-1-acetamido boronic acid alanine …
Matched Iupac: … [(2S)-2-amino-2-carboxyethoxy][(1S)-1-acetamido-2-(naphthalen-1-yl)ethyl]dihydroxyboranuide …
Matched Iupac: … [(2S)-2-amino-2-carboxyethoxy][(1S)-1-acetamido-2-(naphthalen-1-yl)ethyl]dihydroxyboranuide …
L-naphthyl-1-acetamido boronic acid alanine
Experimental
Matched Name: … L-naphthyl-1-acetamido boronic acid alanine …
Matched Iupac: … [(2S)-2-amino-2-carboxyethoxy][(1R)-1-acetamido-2-(naphthalen-1-yl)ethyl]dihydroxyboranuide …
Matched Iupac: … [(2S)-2-amino-2-carboxyethoxy][(1R)-1-acetamido-2-(naphthalen-1-yl)ethyl]dihydroxyboranuide …
Vinpocetine
Vinpocetine has been investigated for the treatment of Epilepsy.
Investigational
Matched Categories: … Heterocyclic Compounds, 2-Ring …
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
Experimental
Matched Name: … N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE …
Coronavirus-Like Particle COVID-19 Vaccine
The Coronavirus-Like Particle COVID-19 Vaccine is in development and testing through Meidcago in Quebec City, Canada. The vaccine was developed by creating SARS-Cov-2 virus-like particles (CoVLPs), which mimic the structure of the virus without carrying the genetic components required for infection. VLPs are thought to have multiple mechanisms involving the...
Investigational
Matched Description: … The vaccine was developed by creating SARS-Cov-2 virus-like particles (CoVLPs), which mimic the structure ... A Phase 1 clinical trial was launched in July 2020 evaluating the safety, tolerability, and immunogenicity …
5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine
Experimental
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide
Experimental
3,4-Dihydro-2'-deoxyuridine-5'-monophosphate
Experimental
Matched Name: … 3,4-Dihydro-2'-deoxyuridine-5'-monophosphate …
Matched Iupac: … {[(2R,3S,5R)-3-hydroxy-5-[(4R)-4-hydroxy-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl]oxolan-2-yl]methoxy}phosphonic …
Matched Iupac: … {[(2R,3S,5R)-3-hydroxy-5-[(4R)-4-hydroxy-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl]oxolan-2-yl]methoxy}phosphonic …
N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
Experimental
Displaying drugs 8726 - 8750 of 9333 in total