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Displaying drugs 10251 - 10275 of 13062 in total

RRx-001

RRx-001 has been used in trials studying the treatment of Lymphomas, Brain Metastases, Cholangiocarcinoma, Colorectal Neoplasms, and Malignant Solid Tumor, among others.
Investigational
Matched Iupac: … 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Butafenacil

Butafenacil is under investigation in clinical trial NCT03760328 (Effect of Upper Airway Stimulation in Patients With Obstructive Sleep Apnea).
Investigational
Matched Iupac: … prop-2-en-1-yl 2-{2-chloro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

5'-O-(L-Cysteinylsulfamoyl)adenosine

Experimental
Matched Iupac: … amino]-3-sulfanylpropan-1-one ... (2R)-2-amino-1-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}sulfonyl) …

Bevifimod

Bevifimod is under investigation in clinical trial NCT01749787 (Safety Study of PRTX-100 With Methotrexate or Leflunomide to Treat Active Rheumatoid Arthritis).
Investigational

Chlorophetanol

Chlorophetanol is an agent known to have antifungal activities.
Experimental
Matched Synonyms: … 2-(4-Chlorophenoxy)ethanol ... 2-(4-chlorphenoxy)-ethanol …
Matched Iupac: … 2-(4-chlorophenoxy)ethan-1-ol …
Matched Categories: … 2-(4-chlorphenoxy)-ethanol …

(3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE

Experimental
Matched Iupac: … (1R,3R,5S)-8,8-dimethyl-3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yloxy}-8-azabicyclo …

Theralizumab

Theralizumab is a humanized anti-CD28 monoclonal antibody designed for treating autoimmune diseases and cancer. After the first human trial, it was withdrawn due to severe toxicity (likely due to lymphopenia and human cytokine release).[A216527,A216532]
Investigational

2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol

Experimental

EB003

EB003 is a CRISPR-based sequence-specific antimicrobial (SSAM) targeted against shiga toxin-producing E. coli.
Investigational

3-Fluoro-L-tyrosine

3-Fluoro-L-tyrosine is a solid. This compound belongs to the phenylpropanoic acids. These are compounds whose structure contain a benzene ring conjugated to a propanoic acid. 3-Fluoro-L-tyrosine targets the protein superoxide dismutase [mn], mitochondrial.
Experimental
Matched Iupac: … (2S)-2-amino-3-(3-fluoro-4-hydroxyphenyl)propanoic acid …

anti-OX40 antibody BMS 986178

A macrocyclic peptide (BMS-986189) with activity in binding and functional assays comparable to a PD-L1 antibody.
Investigational

NBL-015

Investigational

[{(5-Chloro-2-Pyridinyl)Amino} Methylene]-1,1-Bisphosphonate

Experimental

N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

Experimental

Detomidine

Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as Dormosedan. Currently, it is only approved by the FDA for use in horses but has been studied for...
Vet approved
Matched Synonyms: … 4-(2,3-dimethylbenzyl)imidazole …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Reversine

Experimental
Matched Synonyms: … 2-(4-morpholinoanilino)-6-cyclohexylaminopurine …
Matched Iupac: … N6-cyclohexyl-N2-[4-(morpholin-4-yl)phenyl]-9H-purine-2,6-diamine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Eftansomatropin alfa

Eftansomatropin alfa (GX-H9) comprises a recombinant human growth hormone fused to hyFc, a synthetic hybrid Fc fragment. It is under investigation for the treatment of growth hormone deficiency.
Investigational

2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid

Experimental
Matched Name: … 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid …
Matched Iupac: … (2S)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Diclazuril

Diclazuril is a coccidiostat.
Investigational
Vet approved
Matched Iupac: … 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-2-yl)phenyl]acetonitrile …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Brivanib alaninate

Brivanib alaninate has been investigated for the treatment of Colorectal Cancer.
Investigational
Matched Iupac: … (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Brivanib

Brivanib is under investigation for the treatment of HepatoCellular Carcinoma. Brivanib has been investigated for the treatment of Solid Tumors, Hepato Cellular Carcinoma (HCC), and Metastatic Colorectal Cancer (MCRC).
Investigational
Matched Iupac: … (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Naquotinib

Naquotinib has been used in trials studying the treatment of Solid Tumors, Non-small Cell Lung Cancer, Non-Small-Cell Lung Cancer (NSCLC), Epidermal Growth Factor Receptor Mutations, and Epidermal Growth Factor Receptor (EGFR) Mutations, among others.
Investigational
Matched Iupac: … 6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-{[(3R)-1-(prop-2-enoyl)pyrrolidin …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Prenoxdiazine

Experimental
Matched Iupac: … 1-{2-[3-(2,2-diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl}piperidine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

INCB-057643

INCB-057643 is under investigation in clinical trial NCT02959437 (Azacitidine Combined With Pembrolizumab and Epacadostat in Subjects With Advanced Solid Tumors (ECHO-206)).
Investigational
Matched Iupac: … 6-methanesulfonyl-2,2,4-trimethyl-8-{6-methyl-7-oxo-1H,6H,7H-pyrrolo[2,3-c]pyridin-4-yl}-3,4-dihydro- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

CYNK-001

CYNK-001 is a novel allogenic off-the-shelf natural killer (NK) cell therapy originating from human placental CD34+ hematopoietic stem cells and enriched with CD56+/CD3-.
Investigational
Displaying drugs 10251 - 10275 of 13062 in total