Displaying drugs 10826 - 10850 of 11800 in total
Pegtarviliase
Pegtarviliase is under investigation in clinical trial NCT05154890 (A Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS Deficiency).
Investigational
Matched Description: … Pegtarviliase is under investigation in clinical trial NCT05154890 (A Multiple Ascending Dose Study of …
Mivelsiran
Mivelsiran is under investigation in clinical trial NCT06393712 (A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy).
Investigational
Matched Description: … Mivelsiran is under investigation in clinical trial NCT06393712 (A Phase 2 Trial of ALN-APP in Patients …
TTP889
TTP889, an orally bioavailable selective inhibitor of the intrinsic coagulation pathway, is being developed as an anticoagulant for the treatment of thromboembolic disorders. TTP889 is the only known selective small molecule inhibitor of Factor IX, a key enzyme of the intrinsic pathway of the blood coagulation system. TTP889 has proven...
Investigational
Matched Description: … TTP889 is the only known selective small molecule inhibitor of Factor IX, a key enzyme of the intrinsic …
Fiboflapon
Investigational
Omapatrilat
Omapatrilat is an investigational drug that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in urine, dilating blood vessels, and reducing preload and ventricular remodeling. This drug from BMS was not approved by the FDA due...
Investigational
KW-7158
KW-7158 is a tricyclic compound with a non-cholingergic mechanism of action for the treatment of "urinary urgency," "frequent urination" and "urinary incontinence" associated with bladder overactivity (involuntary abnormal contraction of the bladder). The therapeutic effects of KW-7158 in overactive bladder may be due to the activation of A-type K(+) channels...
Investigational
Matched Description: … KW-7158 is a tricyclic compound with a non-cholingergic mechanism of action for the treatment of "urinary ... The therapeutic effects of KW-7158 in overactive bladder may be due to the activation of A-type K(+) …
GEM-231
GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types...
Investigational
Matched Description: … A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid ... GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory …
FAV-201
FAV-201 is a patient-specific immunotherapy for the treatment of T-cell lymphoma.
Investigational
Matched Description: … FAV-201 is a patient-specific immunotherapy for the treatment of T-cell lymphoma. …
Lexatumumab
Lexatumumab is a fully humanized, high-affinity immunoglobulin G(1 lambda) monoclonal antibody (mAb).
Investigational
Matched Description: … Lexatumumab is a fully humanized, high-affinity immunoglobulin G(1 lambda) monoclonal antibody (mAb). …
Perifosine
Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.
Investigational
Matched Description: … Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase …
DiaPep 277
DiaPep 277 is a 24-mer laboratory-made peptide derived from Hsp60(437-460).
Investigational
Matched Description: … DiaPep 277 is a 24-mer laboratory-made peptide derived from Hsp60(437-460). …
Teclozan
Teclozan is an antiprotozoal agent employed typically as a therapy to treat protozoan infections.
Experimental
Matched Description: … Teclozan is an antiprotozoal agent employed typically as a therapy to treat protozoan infections. …
SCH-58500
SCH-58500 is a recombinant replication-deficient adenovirus vector carrying the human p53 gene.
Investigational
Matched Description: … SCH-58500 is a recombinant replication-deficient adenovirus vector carrying the human p53 gene. …
MDX-1097
MDX-1097 is a chimeric monoclonal antibody directed against the kappa myeloma antigen (KMA).
Investigational
Matched Description: … MDX-1097 is a chimeric monoclonal antibody directed against the kappa myeloma antigen (KMA). …
PT886
PT886 is a bispecific antibody against Claudin 18.2 and cluster of differentiation 47 (CD47)
Investigational
Matched Description: … PT886 is a bispecific antibody against Claudin 18.2 and cluster of differentiation 47 (CD47) …
Emodepside
Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively new class of anthelmintic.
Investigational
Vet approved
Matched Description: … Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, ... is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively …
Isaralgagene civaparvovec
Isaralgagene civaparvovec, formerly known as ST-920, is liver-tropic rAAV 2/6 vector carrying the cDNA for human alpha-galactosidase A (α-Gal A) enzyme. It is developed by Sangamo Therapeutics and investigated in Fabry Disease.
Investigational
Matched Description: … (α-Gal A) enzyme. ... formerly known as ST-920, is liver-tropic rAAV 2/6 vector carrying the cDNA for human alpha-galactosidase A …
SGX-523
A MET receptor tyrosine kinase inhibitor.
Investigational
Matched Description: … A MET receptor tyrosine kinase inhibitor. …
Pipazethate
A non-narcotic oral antitussive agent.
Experimental
Matched Description: … A non-narcotic oral antitussive agent. …
Trimazosin
Trimazosin is a sympatholytic alpha blocker.
Experimental
Matched Description: … Trimazosin is a sympatholytic alpha blocker. …
Niludipine
Niludipine is a calcium channel blocker.
Experimental
Matched Description: … Niludipine is a calcium channel blocker. …
Desfesoterodine
Desfesoterodine is a metabolite of tolterodine.
Experimental
Matched Description: … Desfesoterodine is a metabolite of [tolterodine]. …
R450
R450 is an alpha 1 antagonist that acts to tighten the muscle tone in the bladder. It is being considered for treatment of stress-related urinary incontinence. Phase IIa data for the drug show it reduced the number of incontinent episodes compared to placebo with minimal cardiovascular effects.
Investigational
TAFA-93
TAFA93 is a novel prodrug of the mTOR inhibitor rapamycin which has successfully completed Phase 1 clinical development. mTOR inhibitors are currently used in the prevention of organ rejection in transplantation, the treatment of autoimmune and oncological diseases, and as a component of coated stents for the treatment of coronary...
Investigational
Matched Description: … TAFA93 is a novel prodrug of the mTOR inhibitor rapamycin which has successfully completed Phase 1 clinical ... of organ rejection in transplantation, the treatment of autoimmune and oncological diseases, and as a …
SYNB1891
SYNB1891 is a live, modified strain of the probiotic Escherichia coli Nissle engineered to produce cyclic di-AMP (CDA), a stimulator of the STING (STimulator of INterferon Genes) pathway. SYNB1891 is under investigation in clinical trial NCT04167137 (Safety and Tolerability of SYNB1891 Injection Alone or in Combination With Atezolizumab in Adult...
Investigational
Matched Description: … cyclic di-AMP (CDA), a stimulator of the STING (STimulator of INterferon Genes) pathway. ... SYNB1891 is a live, modified strain of the probiotic _Escherichia coli_ Nissle engineered to produce …
Displaying drugs 10826 - 10850 of 11800 in total