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Displaying drugs 1076 - 1100 of 1322 in total

Apremilast

Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as Roflumilast and Crisaborole.[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July 2019, apremilast was granted...
Approved
Investigational
Matched Description: … It belongs to the same drug class as [Roflumilast] and [Crisaborole]. ... associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and …
Matched Mixtures name: … Mar-apremilast ... Mar-apremilast ... Mar-apremilast …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Mar-apremilast ... OTEZLA FILM-COATED TABLETS 30 MG ... OTEZLA FILM-COATED TABLETS 20 MG …

Abemaciclib

Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for...
Approved
Investigational
Matched Description: … It is either given alone in patients who has undergone endocrine therapy and chemotherapy after the metastasis ... Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6 ... Abemaciclib has been used in trials studying the treatment of melanoma, lymphoma, neoplasm, solid tumor …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Yulareb 50mg film-coated tablets ... Yulareb 150mg film-coated tablets ... VERZENIO FILM-COATED TABLET 50MG …

Brigatinib

Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a...
Approved
Investigational
Matched Description: … Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and ... Brigatinib was developed by Ariad Pharmaceuticals, a subsidiary of Takeda Pharmaceutical Company Limited, and …
Matched Mixtures name: … ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 21 ADET 180 MG ... ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 21 ADET 180 MG ... ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 23 ADET 180 MG …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … ALUNBRIG FILM-COATED TABLET 30mg ... ALUNBRIG FILM-COATED TABLET 90mg ... ALUNBRIG FILM-COATED TABLET 180mg …

Memantine

Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's...
Approved
Investigational
Matched Description: … blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and ... doubling every 20 years, the prevalence of Alzheimer's Disease is predicted to reach 66 million by 2030 and …
Matched Mixtures name: … Memantine and Donepezil Hydrochlorides Extended-release ... Memantine and Donepezil Hydrochlorides Extended-release ... Memantine and Donepezil Hydrochlorides Extended-release …
Matched Categories: … donepezil and memantine ... donepezil, memantine and Ginkgo folium …
Matched Products: … MENTAX 10 MG FILM TABLET,FILM TABLET, 100 ADET ... AXURA 5/10/15/20MG FILM ST ... ALMENTA 15MG FILM TABLET, 28 ADET …

Vericiguat

Vericiguat is a direct stimulator of soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and hospitalizations. A key component of the NO-sGC-cGMP signaling pathway that helps to regulate the cardiovascular system, sGC enzymes are intracellular enzymes found in vascular smooth muscle cells (amongst...
Approved
Investigational
Matched Iupac: … N-(4,6-diamino-2-{5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)carbamate …
Matched Description: … soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and ... messenger, activating a number of downstream signaling cascades that elicit a broad variety of effects, and ... thereby helps to prevent the myocardial and vascular dysfunction associated with decreased sGC activity …
Matched Products: … VERQUVO FILM-COATED TABLET 2.5MG ... VERQUVO FILM-COATED TABLET 10MG ... VERQUVO FILM-COATED TABLET 5MG …

Trimetazidine

Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. Trimetazidine has been studied as a treatment for angina pectoris since the late 1960s.[A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response...
Approved
Investigational
Matched Description: … to myocardial ischemia, activate sodium-hydrogen and sodium-calcium antiport systems. ... [A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response ... [A233215] The increased intracellular calcium decreases contractility. …
Matched Products: … SITOREL MR 35 MG DEĞIŞTIRILMIŞ SALIMLI FILM TABLET,FILM TABLET, 60 ADET ... SITOREL 20 MG FILM TABLET, 60 ADET ... VASOFIX 20 MG FILM TABLET, 60 ADET …

Desogestrel

Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological...
Approved
Matched Synonyms: … 13-Ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17-ol …
Matched Description: … Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane ... family which was largely used in Europe before being approved in the US and Canada. ... [A176339] It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent …
Matched Mixtures name: … Solia ... Marfem 21 ... Marfem 28 …
Matched Categories: … Combination Contraceptives (with Estrogen and derivatives) ... Genito Urinary System and Sex Hormones ... desogestrel and estrogen ... desogestrel and ethinylestradiol ... desogestrel and ethinylestradiol …
Matched Products: … Desirett 75mcg film-coated tablet ... Azalia 0.075 mg film-coated tablet ... DESIRETT 75 MCG FILM KAPLI TABLET ,28 ADET …

Risperidone

Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and...
Approved
Investigational
Matched Description: … mental health conditions including schizophrenia and bipolar disorder. ... D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical ... Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and …
Matched Products: … Mar-risperidone ... RISPERIDON - CT 0.5MG FILM ... WELRIS 1 MG FİLM TABLET, 30 ADET …

Linagliptin

Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding . Linagliptin was approved by...
Approved
Matched Description: … that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and …
Matched Mixtures name: … Glyxambi Film-Coated Tablets 25mg/5mg ... Glyxambi Film-Coated Tablets 10mg/5mg ... GLYXAMBI FILM-COATED TABLETS 25 MG/5 MG …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and linagliptin ... linagliptin and empagliflozin ... metformin, linagliptin and empagliflozin ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … TRAJENTA 5MG FILM-COATED TABLETS ... SNOXX 5 MG FİLM KAPLI TABLET ... TRAJENTA 5 MG FILM KAPLI TABLET …

Dacomitinib

Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on...
Approved
Investigational
Matched Description: … [A40009] Dacomitinib was developed by Pfizer Inc and approved by the FDA on September 27, 2018. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Vizimpro 30 mg Film-Coated Tablets ... Vizimpro 15 mg Film-Coated Tablets ... VIZIMPRO FILM-COATED TABLET 15MG …

Roxadustat

Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels. Roxadustat was first approved...
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Matched Products: … EVRENZO 20 MG FİLM KAPLI TABLET, 12 ADET ... EVRENZO 50 MG FİLM KAPLI TABLET, 12 ADET ... EVRENZO 70 MG FİLM KAPLI TABLET, 12 ADET …

Lurasidone

Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently …
Matched Products: … LEDASON 60 MG FİLM KAPLI TABLET, 30 ADET ... LEDASON 120 MG FİLM KAPLI TABLET, 30 ADET ... LUİGON 20 MG FİLM KAPLI TABLET, 30 ADET …

Mirabegron

Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as solifenacin and darifenacin, it lacks significant antimuscarinic activity, which is...
Approved
Matched Description: … receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and ... amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and ... antimuscarinic activity,[A232553] which is responsible both for the therapeutic effects of these medications and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence …
Matched Products: … BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , 10 TABLET ... BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , 100 TABLET ... BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , 50 TABLET …

Deferiprone

Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired....
Approved
Matched Products: … FERRIPROX FILM-COATED TABLET 500 mg ... Ferriprox 1000mg Film-Coated Tablet ... HİERO 500 MG FİLM KAPLI TABLET, 100 ADET …

Letermovir

Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors. Letermovir has recieved both priority and orphan drug status...
Approved
Investigational
Matched Description: … [A31290] Letermovir has recieved both priority and orphan drug status from the FDA. …
Matched Products: … PREVYMIS 240MG FILM-COATED TABLET ... PREVYMIS 480MG FILM-COATED TABLET ... PREVYMIS FILM COATED TABLET 240MG …

Baloxavir marboxil

Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Iupac: … yl]-9,12-dioxo-5-oxa-1,2,8-triazatricyclo[8.4.0.0^{3,8}]tetradeca-10,13-dien-11-yl]oxy}methyl methyl carbonate …
Matched Categories: … Baloxavir and prodrugs …
Matched Products: … XOFLUZA FILM-COATED TABLET 20MG ... XOFLUZA FILM-COATED TABLET 40MG ... XOFLUZA FILM COATED TABLETS 20MG …

Tenofovir alafenamide

Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and ... alafenamide is indicated to treat chronic hepatitis B,[L6241] treat HIV-1,[L4388,L6277,L6280,L6283] and ... [L4388,L9010] Tenofovir alafenamide was developed by Gilead Sciences Inc and granted FDA approval …
Matched Mixtures name: … DESCOVY FILM COATED TABLET 200 MG/25 MG ... DESCOVY FILM COATED TABLET 200 MG/10 MG ... ODEFSEY FILM-COATED TABLET 200MG/25MG/25MG …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Tenofovir and prodrugs ... emtricitabine and tenofovir alafenamide ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors ... emtricitabine, tenofovir alafenamide and rilpivirine …
Matched Products: … VEMLIDY FILM COATED TABLET 25 MG ... VEMLİDY 25 MG FİLM KAPLI TABLET, 30 ADET ... VEMLİDY 25 MG FİLM KAPLI TABLET, 90 ADET …

Alpelisib

Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target...
Approved
Investigational
Matched Description: … children who require systemic therapy. ... that plays a role in various biological processes, including proliferation, survival, differentiation, and ... Alpelisib is marketed under the trade name Piqray and is available as oral tablets. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Trezilent 50mg Film-Coated Tablets ... Trezilent 200mg Film-Coated Tablets ... Trezilent 150mg Film-Coated Tablets …

Gabapentin

Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic...
Approved
Investigational
Matched Description: … It is structurally and functionally related to another GABA derivative, [pregabalin]. ... other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Gabapentin and Prodrugs …
Matched Products: … Mar-gabapentin ... Mar-gabapentin Tabs ... GEMUDA 100 MG FILM TABLET , FILM TABLET, 20 ADET …

Lipoic acid

A vitamin-like antioxidant.
Approved
Investigational
Nutraceutical
Matched Mixtures name: … PIONAL 15/500/300 MG FILM TABLET, 60 ADET ... PIONAL 15/500/300 MG FILM TABLET, 90 ADET ... PIONAL 15/850/300 MG FILM TABLET, 60 ADET …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes ... Various Alimentary Tract and Metabolism Products …
Matched Products: … ALATAB 600 MG FİLM TABLET, 30 ADET ... ALFAZAN 600 MG FİLM TABLET, 30 ADET ... TIOPATI 600 MG FILM TABLET, 30 ADET …

Deferasirox

Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Approved
Investigational
Matched Description: … Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload …
Matched Products: … JADENU FILM COATED TABLET 90MG ... JADENU FILM COATED TABLET 180MG ... JADENU FILM COATED TABLET 360MG …

Daclatasvir

Daclatasvir is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. It is marketed under the name DAKLINZA and is contained in daily oral tablets as the hydrochloride salt form . Hepatitis C is an infectious liver disease...
Approved
Investigational
Matched Iupac: … -1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate …
Matched Description: … Combination therapies that include daclatasir can be used for challenging-to-treat patients who have ... direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and ... Daclatasvir is shown to target both the cis- and trans-acting functions of NS5A and disrupts the function …
Matched Categories: … Amino Acids, Peptides, and Proteins ... daclatasvir, asunaprevir and beclabuvir …
Matched Products: … DAKLINZA 30 MG FILM KAPLI TABLET ,FILM KAPLI TABLET, 28 ADET ... DAKLINZA 60 MG FILM KAPLI TABLET ,FILM KAPLI TABLET, 28 ADET ... Daclavir 60mg Film Coated Tablet …

Ribociclib

Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play...
Approved
Investigational
Matched Description: … that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and ... These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. ... FDA in March, 2017 as Kisqali. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … KISQALI FILM-COATED TABLET 200MG ... Kryxana 200mg Film-coated Tablets ... VALAMOR 200 MG FİLM KAPLI TABLET, 63 ADET …

Lercanidipine

Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Approved
Investigational
Matched Description: … Lercanidipine is a calcium channel blocker of the dihydropyridine class. …
Matched Mixtures name: … ZANITEK 10 MG/10MG FILM TABLET,90 ADET ... ZANITEK 10 MG/10MG FILM TABLET, 30 ADET ... ZANITEK 20 MG/10MG FILM TABLET, 30 ADET …
Matched Categories: … ACE Inhibitors and Calcium Channel Blockers ... Calcium-Regulating Hormones and Agents ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers ... valsartan and lercanidipine ... enalapril and lercanidipine …
Matched Products: … ZANIDIP 10MG FILM COATED TABLETS ... Zanidip 20mg, film-coated tablet ... LERCADIP 10 MG FILM TABLET, 30 ADET …

Bosutinib

Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor,...
Approved
Matched Description: … Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine ... BCR-ABL inhibitors like bosutinib inhibit most resistance-conferring BCR-ABL mutations except V299L and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … BOSULİF 500 MG FİLM KAPLI TABLET, 28 ADET ... BOSULİF 500 MG FİLM KAPLI TABLET, 30 ADET ... BOSULİF 100 MG FİLM KAPLI TABLET, 28 ADET …
Displaying drugs 1076 - 1100 of 1322 in total