Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid.

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Sinniah R, Lye WC

Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid.

Clin Nephrol. 2001 Mar;55(3):254-8.

PubMed ID

11316248 [ View in PubMed

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Abstract

Mefenamic acid ingestion, usually in excess and over prolonged period is known to produce interstitial nephritis, or less commonly papillary necrosis, with acute renal failure. However, it is not dose-dependent for the induction of tubulointerstitial damage. Excess iodine ingestion is known to produce toxicity and possible death, but acute renal failure is rare. There is evidence from clinical and experimental data that iodine has toxic effect on tubular epithelial cells. Iodine has not been documented to produce red cell hemolysis and hemoglobinuria. We present a unique case of acute renal failure from hemoglobinuric and acute interstitial nephritis secondary to suicidal ingestion of potassium iodide solution and also ingestion of a few mefenamic acid tablets. These agents led to potentiation of the renal injury from hemoglobinuric tubulopathy, probably from the iodine, and renal dysfunction from alteration of renal perfusion by selective COX-1 inhibition of prostaglandin production, and induction of acute interstitial nephritis from mefenamic acid, leading to acute renal failure which was reversible by hemodialysis and supportive therapy.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Mefenamic acid	Prostaglandin G/H synthase 1	Protein	Humans	Unknown	Inhibitor	Details