Cocaine pharmacology and current pharmacotherapies for its abuse.
Article Details
- CitationCopy to clipboard
Carrera MR, Meijler MM, Janda KD
Cocaine pharmacology and current pharmacotherapies for its abuse.
Bioorg Med Chem. 2004 Oct 1;12(19):5019-30.
- PubMed ID
- 15351386 [ View in PubMed]
- Abstract
Cocaine abuse continues to be prevalent and effective therapies for cocaine craving and addiction remain elusive. In the last decade immunopharmacotherapy has been proposed as a promising means to alleviate this illness. By using the organism's natural immune response, an anti-cocaine vaccine promotes the production of cocaine-specific antibodies that sequester the drug before their passage into the brain, where it exerts its reinforcing and thus addictive effects. A series of studies demonstrating the cocaine-blocking properties of various immunogenic conjugates will be reviewed in the context of the neuropsychopharmacological profile of the drug.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cocaine Muscarinic acetylcholine receptor M1 Protein Humans UnknownAntagonistDetails Cocaine Muscarinic acetylcholine receptor M2 Protein Humans UnknownAntagonistDetails Cocaine Sodium-dependent dopamine transporter Protein Humans YesInhibitorDetails Cocaine Sodium-dependent noradrenaline transporter Protein Humans YesInhibitorDetails Cocaine Sodium-dependent serotonin transporter Protein Humans YesInhibitorDetails