[Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression].

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Nolen WA

[Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression].

Ned Tijdschr Geneeskd. 2003 Oct 4;147(40):1940-3.

PubMed ID

14574774 [ View in PubMed

]

Abstract

In the Netherlands monoamine oxidase (MAO) inhibitors are not registered for the treatment of patients with depression. The classical, nonselective MAO inhibitors--phenelzine and tranylcypromine--are effective but their use is associated with interactions (with tyramine in food, sympathicomimetics and serotonine re-uptake inhibitors) and side-effects (hypertension, hypotension, headache, sleep disturbances and neuromuscular symptoms in particular). Therefore, the classical MAO inhibitors are indicated only in depressive disorders that are unresponsive to the first stages of treatment. Taking this selection into account, treatment should be long-term to avoid relapse.

DrugBank Data that Cites this Article

Drugs

Tranylcypromine

Phenelzine

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Phenelzine	Amine oxidase [flavin-containing] A	Protein	Humans	Yes	Antagonist	Details
Phenelzine	Amine oxidase [flavin-containing] B	Protein	Humans	Yes	Antagonist	Details
Tranylcypromine	Amine oxidase [flavin-containing] A	Protein	Humans	Yes	Inhibitor	Details
Tranylcypromine	Amine oxidase [flavin-containing] B	Protein	Humans	Yes	Inhibitor	Details