Amine oxidase [flavin-containing] A

Details

Name
Amine oxidase [flavin-containing] A
Synonyms
  • 1.4.3.21
  • 1.4.3.4
  • MAO-A
  • Monoamine oxidase type A
Gene Name
MAOA
UniProtKB Entry
P21397Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0004313|Amine oxidase [flavin-containing] A
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Number of residues
527
Molecular Weight
59681.27
Theoretical pI
7.96
GO Classification
Functions
aliphatic amine oxidase activity / monoamine oxidase activity
Processes
biogenic amine metabolic process / positive regulation of signal transduction
Components
cytosol
General Function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity)
Specific Function
aliphatic amine oxidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
498-518
Cellular Location
Mitochondrion outer membrane
Gene sequence
>lcl|BSEQ0011589|Amine oxidase [flavin-containing] A (MAOA)
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCAGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA
Chromosome Location
X
Locus
Xp11.3
External Identifiers
ResourceLink
UniProtKB IDP21397
UniProtKB Entry NameAOFA_HUMAN
GenBank Protein ID187353
GenBank Gene IDM68840
GeneCard IDMAOA
GenAtlas IDMAOA
HGNC IDHGNC:6833
PDB ID(s)2BXR, 2BXS, 2Z5X, 2Z5Y
KEGG IDhsa:4128
IUPHAR/Guide To Pharmacology ID2489
NCBI Gene ID4128
General References
  1. Hsu YP, Weyler W, Chen S, Sims KB, Rinehart WB, Utterback MC, Powell JF, Breakefield XO: Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences. J Neurochem. 1988 Oct;51(4):1321-4. [Article]
  2. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH, Shih JC: cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4934-8. [Article]
  3. Chen ZY, Hotamisligil GS, Huang JK, Wen L, Ezzeddine D, Aydin-Muderrisoglu N, Powell JF, Huang RH, Breakefield XO, Craig I, et al.: Structure of the human gene for monoamine oxidase type A. Nucleic Acids Res. 1991 Aug 25;19(16):4537-41. [Article]
  4. Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC: Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3637-41. [Article]
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  8. Zhu QS, Grimsby J, Chen K, Shih JC: Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J Neurosci. 1992 Nov;12(11):4437-46. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Amine oxidase [flavin-containing] A (Humans)protein
primary
Monoamine oxidase (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Flavin adenine dinucleotideapprovedyestargetinhibitorDetails
IsocarboxazidapprovedyestargetinhibitorDetails
Moclobemideapproved, investigationalyestargetantagonistinhibitorDetails
PhenelzineapprovedyestargetantagonistDetails
Tranylcypromineapproved, investigationalyestargetinhibitorDetails
Phentermineapproved, illicityestargetantagonistDetails
PosizolidinvestigationalunknowntargetDetails
CX157investigationalunknowntargetDetails
PhenylephrineapprovedunknownenzymesubstrateDetails
Phenylpropanolamineapproved, vet_approved, withdrawnunknownenzymeinhibitorDetails
Sumatriptanapproved, investigationalunknownenzymesubstrateDetails
PseudoephedrineapprovedunknownenzymeinhibitorDetails
RizatriptanapprovedunknownenzymesubstrateDetails
Bufotenineexperimental, illicitunknownenzymesubstrateDetails
Linezolidapproved, investigationalnoenzymeinhibitorDetails
PhenelzineapprovedunknownenzymesubstrateDetails
Moclobemideapproved, investigationalunknownenzymeinhibitorDetails
Riboflavinapproved, investigational, nutraceutical, vet_approvedunknownenzymecofactorDetails
Zolmitriptanapproved, investigationalunknownenzymesubstrateDetails
Testosteroneapproved, investigationalunknownenzymeinducerDetails
Almotriptanapproved, investigationalunknownenzymesubstrateDetails
DopamineapprovedunknownenzymesubstrateDetails
Selegilineapproved, investigational, vet_approvednotargetinhibitorDetails
SertralineapprovedunknownenzymesubstrateDetails
Zonisamideapproved, investigationalunknowntargetinhibitorDetails
Decyl(dimethyl)phosphine oxideexperimentalyestargetinhibitorDetails
HarmineexperimentalyestargetinhibitorDetails
ClorgilineexperimentalyestargetinhibitorDetails
MinaprineapprovedyestargetinhibitorDetails
PargylineapprovedunknowntargetinhibitorDetails
4-Methoxyamphetamineexperimental, illicityestargetinhibitorDetails
Ephedra sinica rootnutraceuticalyestargetinhibitorDetails
MMDAexperimental, illicityestargetinhibitorDetails
Metamfetamineapproved, illicit, withdrawnyestargetinhibitorDetails
NicotineapprovedunknownenzymeinhibitorDetails
Furazolidoneexperimental, vet_approvedunknownenzymeinhibitorDetails
Zimelidineapproved, withdrawnunknowntargetinhibitorDetails
Nialamideapproved, withdrawnunknowntargetDetails
Nomifensineapproved, withdrawnunknowntargetDetails
CapsaicinapprovedunknownenzymeinhibitorDetails
Nandrolone decanoateapproved, illicitunknownenzymeinhibitorDetails
Naratriptanapproved, investigationalunknownenzymesubstrateDetails
Safinamideapproved, investigationalunknownenzymeinhibitorDetails
Oxymetholoneapproved, illicitunknownenzymeinducerDetails
BrofaromineexperimentalunknowntargetinhibitorDetails
Testosterone cypionateapprovedunknownenzymeinducerDetails
Testosterone enanthateapprovedunknownenzymeinducerDetails
Testosterone undecanoateapproved, investigationalunknownenzymeinducerDetails
ToloxatoneexperimentalunknowntargetantagonistDetails
ToloxatoneexperimentalyesenzymeinhibitorDetails
PirlindoleexperimentalunknowntargetantagonistDetails
PirlindoleexperimentalunknownenzymeinhibitorDetails
Eravacyclineapproved, investigationalnoenzymesubstrateDetails
Propranololapproved, investigationalunknownenzymeinhibitorDetails
BicifadineinvestigationalunknownenzymesubstrateDetails
IproniazidwithdrawnunknownenzymeinhibitorDetails
Ubrogepantapproved, investigationalunknownenzymeinhibitorDetails
Tedizolidapproved, investigationalnoenzymeinhibitorDetails
Tedizolid phosphateapprovednoenzymeinhibitorDetails
Flortaucipir F-18approved, investigationalnotargetbinderDetails
Ginkgo bilobaapproved, investigational, nutraceuticalunknowntargetinhibitorDetails
Viloxazineapproved, investigational, withdrawnunknowntargetinhibitorDetails
EscitalopramapprovednoenzymesubstrateDetails
CitalopramapprovednoenzymesubstrateDetails
7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDEexperimentalyestargetinhibitorDetails
IproniazidwithdrawnyestargetinhibitorDetails
BifemelaneexperimentalyestargetmodulatorDetails
PiperineinvestigationalyestargetinhibitorDetails
IndantadolinvestigationalyestargetinhibitorDetails
LadostigilinvestigationalyestargetinhibitorDetails
PsoraleninvestigationalyestargetinhibitorDetails
TryptamineexperimentalyestargetinhibitorDetails
Procaineapproved, investigational, vet_approvedunknowntargetinhibitorDetails
Amphetamineapproved, illicit, investigationalyestargetinhibitorDetails
Procarbazineapproved, investigationalyestargetinhibitorDetails
Copperapproved, investigationalunknownenzymecofactorDetails
Moclobemideapproved, investigationalunknowntargetantagonistDetails
Rauwolfia serpentina rootinvestigationalunknownenzymesubstrateDetails
Epinephrineapproved, vet_approvedunknownenzymesubstrateDetails
Betahistineapproved, investigationalunknownenzymesubstrateDetails