Amine oxidase [flavin-containing] A
Details
- Name
- Amine oxidase [flavin-containing] A
- Synonyms
- 1.4.3.21
- 1.4.3.4
- MAO-A
- Monoamine oxidase type A
- Gene Name
- MAOA
- UniProtKB Entry
- P21397Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004313|Amine oxidase [flavin-containing] A MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
- Number of residues
- 527
- Molecular Weight
- 59681.27
- Theoretical pI
- 7.96
- GO Classification
- Functionsaliphatic amine oxidase activity / monoamine oxidase activityProcessesbiogenic amine metabolic process / positive regulation of signal transductionComponentscytosol
- General Function
- Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity)
- Specific Function
- aliphatic amine oxidase activity
- Pfam Domain Function
- Amino_oxidase (PF01593)
- Signal Regions
- Not Available
- Transmembrane Regions
- 498-518
- Cellular Location
- Mitochondrion outer membrane
- Gene sequence
>lcl|BSEQ0011589|Amine oxidase [flavin-containing] A (MAOA) ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC AAGCCAGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA TACAAGCTCCTGCCACGGTCTTGA
- Chromosome Location
- X
- Locus
- Xp11.3
- External Identifiers
Resource Link UniProtKB ID P21397 UniProtKB Entry Name AOFA_HUMAN GenBank Protein ID 187353 GenBank Gene ID M68840 GeneCard ID MAOA GenAtlas ID MAOA HGNC ID HGNC:6833 PDB ID(s) 2BXR, 2BXS, 2Z5X, 2Z5Y KEGG ID hsa:4128 IUPHAR/Guide To Pharmacology ID 2489 NCBI Gene ID 4128 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Amine oxidase [flavin-containing] A (Humans) protein primaryMonoamine oxidase (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Flavin adenine dinucleotide approved yes target inhibitor Details Isocarboxazid approved yes target inhibitor Details Moclobemide approved, investigational yes target antagonistinhibitor Details Phenelzine approved yes target antagonist Details Tranylcypromine approved, investigational yes target inhibitor Details Phentermine approved, illicit yes target antagonist Details Posizolid investigational unknown target Details CX157 investigational unknown target Details Phenylephrine approved unknown enzyme substrate Details Phenylpropanolamine approved, vet_approved, withdrawn unknown enzyme inhibitor Details Sumatriptan approved, investigational unknown enzyme substrate Details Pseudoephedrine approved unknown enzyme inhibitor Details Rizatriptan approved unknown enzyme substrate Details Bufotenine experimental, illicit unknown enzyme substrate Details Linezolid approved, investigational no enzyme inhibitor Details Phenelzine approved unknown enzyme substrate Details Moclobemide approved, investigational unknown enzyme inhibitor Details Riboflavin approved, investigational, nutraceutical, vet_approved unknown enzyme cofactor Details Zolmitriptan approved, investigational unknown enzyme substrate Details Testosterone approved, investigational unknown enzyme inducer Details Almotriptan approved, investigational unknown enzyme substrate Details Dopamine approved unknown enzyme substrate Details Selegiline approved, investigational, vet_approved no target inhibitor Details Sertraline approved unknown enzyme substrate Details Zonisamide approved, investigational unknown target inhibitor Details Decyl(dimethyl)phosphine oxide experimental yes target inhibitor Details Harmine experimental yes target inhibitor Details Clorgiline experimental yes target inhibitor Details Minaprine approved yes target inhibitor Details Pargyline approved unknown target inhibitor Details 4-Methoxyamphetamine experimental, illicit yes target inhibitor Details Ephedra sinica root nutraceutical yes target inhibitor Details MMDA experimental, illicit yes target inhibitor Details Metamfetamine approved, illicit, withdrawn yes target inhibitor Details Nicotine approved unknown enzyme inhibitor Details Furazolidone experimental, vet_approved unknown enzyme inhibitor Details Zimelidine approved, withdrawn unknown target inhibitor Details Nialamide approved, withdrawn unknown target Details Nomifensine approved, withdrawn unknown target Details Capsaicin approved unknown enzyme inhibitor Details Nandrolone decanoate approved, illicit unknown enzyme inhibitor Details Naratriptan approved, investigational unknown enzyme substrate Details Safinamide approved, investigational unknown enzyme inhibitor Details Oxymetholone approved, illicit unknown enzyme inducer Details Brofaromine experimental unknown target inhibitor Details Testosterone cypionate approved unknown enzyme inducer Details Testosterone enanthate approved unknown enzyme inducer Details Testosterone undecanoate approved, investigational unknown enzyme inducer Details Toloxatone experimental unknown target antagonist Details Toloxatone experimental yes enzyme inhibitor Details Pirlindole experimental unknown target antagonist Details Pirlindole experimental unknown enzyme inhibitor Details Eravacycline approved, investigational no enzyme substrate Details Propranolol approved, investigational unknown enzyme inhibitor Details Bicifadine investigational unknown enzyme substrate Details Iproniazid withdrawn unknown enzyme inhibitor Details Ubrogepant approved, investigational unknown enzyme inhibitor Details Tedizolid approved, investigational no enzyme inhibitor Details Tedizolid phosphate approved no enzyme inhibitor Details Flortaucipir F-18 approved, investigational no target binder Details Ginkgo biloba approved, investigational, nutraceutical unknown target inhibitor Details Viloxazine approved, investigational, withdrawn unknown target inhibitor Details Escitalopram approved no enzyme substrate Details Citalopram approved no enzyme substrate Details 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE experimental yes target inhibitor Details Iproniazid withdrawn yes target inhibitor Details Bifemelane experimental yes target modulator Details Piperine investigational yes target inhibitor Details Indantadol investigational yes target inhibitor Details Ladostigil investigational yes target inhibitor Details Psoralen investigational yes target inhibitor Details Tryptamine experimental yes target inhibitor Details Procaine approved, investigational, vet_approved unknown target inhibitor Details Amphetamine approved, illicit, investigational yes target inhibitor Details Procarbazine approved, investigational yes target inhibitor Details Copper approved, investigational unknown enzyme cofactor Details Moclobemide approved, investigational unknown target antagonist Details Rauwolfia serpentina root investigational unknown enzyme substrate Details Epinephrine approved, vet_approved unknown enzyme substrate Details Betahistine approved, investigational unknown enzyme substrate Details