Effect of cephalosporins on bilirubin-albumin binding.

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Robertson A, Fink S, Karp W

Effect of cephalosporins on bilirubin-albumin binding.

J Pediatr. 1988 Feb;112(2):291-4.

PubMed ID
3339510 [ View in PubMed
]
Abstract

The effect of parenterally administered cephalosporins on bilirubin-albumin binding was measured in vitro by means of the peroxidase method with human serum albumin and by means of a dialysis rate method with newborn infants' serum. Ceftriaxone and cefoperazone have been shown to affect bilirubin-albumin binding. In this study, 13 additional cephalosporins were tested. Cefonicid, cefotetan, and cefmetazole competed with bilirubin for albumin binding and, at reported mean peak serum levels, decreased the reserve albumin concentration by 75%, 56%, and 40%, respectively. We suggest that these five cephalosporins may increase the risk of bilirubin encephalopathy in jaundiced neonates.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
CefmetazoleSerum albuminProteinHumans
No
Not AvailableDetails
CefonicidSerum albuminProteinHumans
No
Other/unknown
Details
CefoperazoneSerum albuminProteinHumans
No
Other/unknown
Details
CefotetanSerum albuminProteinHumans
No
Not AvailableDetails
CeftriaxoneSerum albuminProteinHumans
No
Other/unknown
Details