Muromonab CD3. A review of its pharmacology and therapeutic potential.

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Todd PA, Brogden RN

Muromonab CD3. A review of its pharmacology and therapeutic potential.

Drugs. 1989 Jun;37(6):871-99.

PubMed ID
2503348 [ View in PubMed
]
Abstract

Muromonab CD3 (Orthoclone OKT3, Orthoclone, OKT3) is the first monoclonal antibody to become available for therapy in humans. In effect it blocks all cytotoxic T cell function. Clinical trials show that muromonab CD3 is effective in reversing acute renal, hepatic, cardiac and combined kidney-pancreas transplant rejection episodes. It has also been shown to be effective in the treatment of rejections resistant to conventional treatment. As such it offers a significant alternative when no other therapeutic option remains open. Other clinical trials have shown that muromonab CD3 is more effective than high-dose corticosteroids in reversing first episodes of acute renal and hepatic rejection. Additionally, it appears effective as a prophylactic treatment against acute renal and cardiac rejection in the immediate post-transplantation period. Preliminary studies also indicate that it may be effective in preventing or reversing graft-versus-host disease in bone marrow transplant patients. The development of neutralising antibodies may limit the effectiveness of a second course of muromonab CD3 therapy in some patients. In conclusion, muromonab CD3 offers a significant new approach to immunosuppressive therapy and has provided a valuable therapeutic alternative for the treatment of acute solid organ transplant rejection.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
MuromonabT-cell surface glycoprotein CD3 delta chainProteinHumans
Yes
Not AvailableDetails
MuromonabT-cell surface glycoprotein CD3 gamma chainProteinHumans
Yes
Not AvailableDetails
MuromonabT-cell surface glycoprotein CD3 zeta chainProteinHumans
Yes
Not AvailableDetails