A comprehensive analysis of the association of common variants of ABCG2 with gout.

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Yu KH, Chang PY, Chang SC, Wu-Chou YH, Wu LA, Chen DP, Lo FS, Lu JJ

A comprehensive analysis of the association of common variants of ABCG2 with gout.

Sci Rep. 2017 Aug 30;7(1):9988. doi: 10.1038/s41598-017-10196-2.

PubMed ID

28855613 [ View in PubMed

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Abstract

The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were associated with an increased risk of gout with odds ratios (ORs) from 2.59-3.17 (all P < 0.0001). A novel finding in the present study was the identification of rs3114018 in block 3 and its association with increased gout risk. We found that the rs2231142T allele in block 2 and the rs3114018C-rs3109823T (C-T) risk haplotype in block 3 conferred the greatest evidence of association to gout risk (P = 1.19 x 10(-12) and P = 9.20 x 10(-11), respectively). Our study provides an improved understanding of ABCG2 variations in patients with gout and, as shown by haplotype analysis, that ABCG2 may have a role in gout susceptibility.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Allopurinol	ATP-binding cassette sub-family G member 2	Protein	Humans	Unknown	Substrate	Details