Broad substrate specificity ATP-binding cassette transporter ABCG2

BE0001067ProteinHumansABCG2

Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). It is acted on by 340 drugs in DrugBank.

Gene name
ABCG2
UniProtKB entry
Q9UNQ0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
655 residues · 72,313 Da
Also known as
7.6.2.- · 7.6.2.2 · ABCP · ATP-binding cassette sub-family G member 2 · BCRP

Resolves to

Protein
UniProtQ9UNQ0UniProt nameABCG2_HUMAN
Gene
HGNCHGNC:74NCBI Gene9429GenBank4185796GeneCardsABCG2
Pharmacology
IUPHAR/GtoPdb792KEGGhsa:9429
Structure
PDB5NJ3PDB5NJGPDB6ETI
Drugs

What you can answer from here — as of September 03, 2024

340DrugsApproved to experimental, with action, bond type and pharmacological action
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15Clinical trialsTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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577+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Broad substrate specificity ATP-binding cassette transporter ABCG2, how selective are they, and which programs against it are still in active trials?

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