ABCG1 is involved in vitamin E efflux.
Article Details
- CitationCopy to clipboard
Olivier M, BottG R, Frisdal E, Nowick M, Plengpanich W, Desmarchelier C, Roi S, Quinn CM, Gelissen I, Jessup W, Van Eck M, Guerin M, Le Goff W, Reboul E
ABCG1 is involved in vitamin E efflux.
Biochim Biophys Acta. 2014 Dec;1841(12):1741-51. doi: 10.1016/j.bbalip.2014.10.003.
- PubMed ID
- 25462452 [ View in PubMed]
- Abstract
Vitamin E membrane transport has been shown to involve the cholesterol transporters SR-BI, ABCA1 and NPC1L1. Our aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcgl-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues displayed a higher vitamin E content compared to wild-type mice. alpha- and gamma-tocopherol efflux was increased in CHO cells overexpressing human ABCG1 compared to control cells. Conversely, alpha- and gamma- tocopherol efflux was decreased in ABCG1-knockdown human cells (Hep3B hepatocytes and THP-1 macro- phages). Interestingly, alpha- and gamma-tocopherol significantly downregulated ABCG1 and ABCA1 expression levels in Hep3B and THP-1, an effect confirmed in vivo in rats given vitamin E for 5 days. This was likely due to reduced LXR activation by oxysterols, as Hep3B cells and rat liver treated with vitamin E displayed a significantly reduced content in oxysterols compared to their respective controls. Overall, the present study reveals for the first time that ABCG1 is involved in cellular vitamin E efflux.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Vitamin E ATP-binding cassette sub-family A member 1 Protein Humans UnknownSubstrateDetails Vitamin E ATP-binding cassette sub-family G member 1 Protein Humans UnknownSubstrateDetails Vitamin E Niemann-Pick C1-like protein 1 Protein Humans UnknownSubstrateDetails Vitamin E Scavenger receptor class B member 1 Protein Humans UnknownSubstrateDetails