Serotonin receptors - from molecular biology to clinical applications.

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Pytliak M, Vargova V, Mechirova V, Felsoci M

Serotonin receptors - from molecular biology to clinical applications.

Physiol Res. 2011;60(1):15-25. Epub 2010 Oct 15.

PubMed ID
20945968 [ View in PubMed
]
Abstract

Serotonin (5-hydroxytryptamine) is an ubiquitary monoamine acting as one of the neurotransmitters at synapses of nerve cells. Serotonin acts through several receptor types and subtypes. The profusion of 5-HT receptors should eventually allow a better understanding of the different and complex processes in which serotonin is involved. Its role is expected in the etiology of several diseases, including depression, schizophrenia, anxiety and panic disorders, migraine, hypertension, pulmonary hypertension, eating disorders, vomiting and irritable bowel syndromes. In the past 20 years, seven distinct families of 5-HT receptors have been identified and various subpopulations have been described for several of them. Increasing number of 5-HT receptors has made it difficult to unravel the role of 5-HT receptor subpopulations due to the lack of suitable selective agents. The present review describes the different populations and nomenclature of recently discovered 5-HT receptors and their pharmacological relevance.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
5-hydroxytryptamine receptor 1AP08908Details
5-hydroxytryptamine receptor 2BP41595Details
5-hydroxytryptamine receptor 2AP28223Details
5-hydroxytryptamine receptor 1FP30939Details
5-hydroxytryptamine receptor 1EP28566Details
5-hydroxytryptamine receptor 2CP28335Details
5-hydroxytryptamine receptor 1DP28221Details
5-hydroxytryptamine receptor 1BP28222Details