Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with rheumatoid arthritis.

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Thomas GM, Rees P, Dippy JE, Maddock J

Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with rheumatoid arthritis.

Curr Med Res Opin. 1975;3(5):264-7.

PubMed ID

241595 [ View in PubMed

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Abstract

The simultaneous pharmacokinetics of alclofenac in the plasma and synovial fluid of 10 patients with rheumatoid arthritis were studied after a single 1 g. oral dose. A gas-liquid chromatographic method was used for assaying alclofenac in both plasma and synovial fluid. Alclofenac readily appears in the plasma and synovial fluid.

DrugBank Data that Cites this Article

Drugs

Alclofenac

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Alclofenac	Prostaglandin G/H synthase 2	Protein	Humans	Yes	Antagonist	Details