Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with rheumatoid arthritis.

Article Details

Citation

Thomas GM, Rees P, Dippy JE, Maddock J

Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with rheumatoid arthritis.

Curr Med Res Opin. 1975;3(5):264-7.

PubMed ID
241595 [ View in PubMed
]
Abstract

The simultaneous pharmacokinetics of alclofenac in the plasma and synovial fluid of 10 patients with rheumatoid arthritis were studied after a single 1 g. oral dose. A gas-liquid chromatographic method was used for assaying alclofenac in both plasma and synovial fluid. Alclofenac readily appears in the plasma and synovial fluid.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AlclofenacProstaglandin G/H synthase 2ProteinHumans
Yes
Antagonist
Details