Alclofenac is a non-steroidal anti-inflammatory drug. It was withdrawn from the market in the United Kingdom in 1979.
- Mechanism
- Curator reviewed
Alclofenac is an inhibitor of prostaglandin H2 synthase. The inhibition of the enzyme occurs through the reversible block of cyclooxygenase enzyme. Therefore, it prevents the production of inflammatory mediators (and pain) as prostacyclins and prostaglandins. Aclofenac has the ability to inhibit the biosynthesis of prostaglandins which may be an important factor in the action of these drugs, but in addition, the effect of these agents in displacing endogenous anti-inflammatory substances from plasma protein binding sites is thought to be an equally important effect in their mechanism of action
- Primary indication
- Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies.Curator reviewed
- Formula / weight
- C11H11ClO3 · 226.66 g/mol (avg)
- Also known as
- Alclophenac
- Code names
- MY-101 · W-7320
Resolves to
ARHWPKZXBHOEEE-UHFFFAOYSA-NSMILESOC(=O)CC1=CC(Cl)=C(OCC=C)C=C1What you can answer from here — as of June 15, 2026
Which drugs share a target with Alclofenac, and which of those have an active Phase 3 trial?
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