The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning.

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Baskin SI, Horowitz AM, Nealley EW

The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning.

J Clin Pharmacol. 1992 Apr;32(4):368-75.

PubMed ID

1569239 [ View in PubMed

]

Abstract

The combination of sodium thiosulfate and sodium nitrite has been used in the United States since the 1930s as the primary antidote for cyanide intoxication. Although this combination was shown to exhibit much greater efficacy than either ingredient alone, the two compounds could not be used prophylactically because each exhibits a number of side effects. This review discusses the pharmacodynamics, pharmacokinetics, and toxicology of the individual agents, and their combination.

DrugBank Data that Cites this Article

Drugs

Nitrous acid

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Nitrous acid	Hemoglobin subunit alpha	Protein	Humans	Yes	Oxidizer	Details
Nitrous acid	Hemoglobin subunit beta	Protein	Humans	Yes	Oxidizer	Details
Nitrous acid	Myoglobin	Protein	Humans	Unknown	Oxidizer	Details