Binding studies on aluminum(III)-albumin interaction.

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Zatta P, Dalla Via L, Di Noto V

Binding studies on aluminum(III)-albumin interaction.

Arch Biochem Biophys. 2003 Sep 1;417(1):59-64.

PubMed ID
12921780 [ View in PubMed
]
Abstract

The present paper reports a quantitative investigation on the binding of aluminum to human serum albumin. Equilibrium dialysis and a general thermodynamic approach have been used to determine the binding parameters. Two aluminum binding sites have been identified on the albumin molecule, involving sites with single and double occupancy modes. The binding properties of these two distinct sites appear to undergo reciprocal influences, suggesting a possible interaction between the corresponding protein moieties. Both coordination modes proceed from weak interactions, as shown by the binding energies calculated.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
AluminiumSerum albuminProteinHumans
Unknown
Not AvailableDetails
Aluminium phosphateSerum albuminProteinHumans
Unknown
Not AvailableDetails
Aluminum acetateSerum albuminProteinHumans
Unknown
Not AvailableDetails