Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate.

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Eriksson B, Helgstrand E, Johansson NG, Larsson A, Misiorny A, Noren JO, Philipson L, Stenberg K, Stening G, Stridh S, Oberg B

Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate.

Antimicrob Agents Chemother. 1977 Jun;11(6):946-51. doi: 10.1128/aac.11.6.946.

PubMed ID

879760 [ View in PubMed

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Abstract

Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and GpC-stimulated influenza virus ribonucleic acid polymerase. Since ribavirin is phosphorylated in the cell, the inhibition of influenza multiplication in the cell may also be caused by RTP.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ribavirin	RNA-directed RNA polymerase L	Protein	HPIV-2	Yes	Antagonist	Details