Physiology, Plasminogen Activation
Article Details
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Katz JM, Tadi P
Physiology, Plasminogen Activation
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- PubMed ID
- 30969567 [ View in PubMed]
- Abstract
Plasminogen activation results in increased conversion of plasminogen to plasmin, the latter an enzyme that breakdowns the fibrinogen in blood clots. There is a wide usage of tissue plasminogen activators in clinical practice during the treatment of ischemic cerebral vascular events. Since ischemic cerebral vascular events are a leading cause of morbidity in the United States, a general understanding of the physiology of plasminogen activation is critical, both as a base for the utilization of these therapies and an understanding of coagulation homeostasis in the body. This article will serve as a review of plasminogen activation with a discussion on inhibitors of plasminogen activation and will conclude with a short discussion on medical thrombolytic therapy.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Plasminogen Tissue-type plasminogen activator Protein Humans UnknownSubstrateDetails Plasminogen Urokinase-type plasminogen activator Protein Humans UnknownSubstrateDetails - Drug Reactions
Reaction Details
