Urokinase-type plasminogen activator

BE0000895ProteinHumansPLAU

Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin (PubMed:1969415, PubMed:2521625, PubMed:4270330). It is acted on by 43 drugs in DrugBank.

Gene name
PLAU
UniProtKB entry
P00749Swiss-Prot
Cellular location
Secreted
Residues / weight
431 residues · 48,523 Da
Also known as
3.4.21.73 · U-plasminogen activator · uPA · Urokinase

Resolves to

Protein
UniProtP00749UniProt nameUROK_HUMAN
Gene
HGNCHGNC:9052NCBI Gene5328GenBank1834524GeneCardsPLAU
Pharmacology
IUPHAR/GtoPdb2393KEGGhsa:5328
Structure
PDB1C5WPDB1C5XPDB1C5Y
Drugs

What you can answer from here — as of September 07, 2019

43DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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151+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Urokinase-type plasminogen activator, how selective are they, and which programs against it are still in active trials?

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