Single doses of ritodrine delay orocaecal transit in patients with irritable bowel syndrome.

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Basilisco G, Camboni MG, Bozzani A, Molgora M, Bianchi PA

Single doses of ritodrine delay orocaecal transit in patients with irritable bowel syndrome.

Br J Clin Pharmacol. 1990 Mar;29(3):355-8. doi: 10.1111/j.1365-2125.1990.tb03647.x.

PubMed ID

2310659 [ View in PubMed

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Abstract

The lactulose hydrogen breath test was used to assess the effect of a single dose of the beta 2-adrenoceptor agonist ritodrine on orocaecal transit time in 11 patients (three men) with irritable bowel syndrome. Transit time (median values, range) was significantly longer (P less than 0.01) after ritodrine than after placebo (120, 50-200 vs 75, 40-100 min). Median heart rate was similar before treatments whereas the maximal increase in heart rate was significantly greater (P less than 0.01) after ritodrine than after placebo.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ritodrine	Beta-2 adrenergic receptor	Protein	Humans	Yes	Agonist	Details