[Effects of propranolol and metoprolol on beta-adrenergic metabolic responses (author's transl)].

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Chowanetz W, Muller K, Gross W

[Effects of propranolol and metoprolol on beta-adrenergic metabolic responses (author's transl)].

Med Klin. 1979 Sep 7;74(36):1286-90.

PubMed ID

492050 [ View in PubMed

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Abstract

In ten healthy volunteers infusion of 7 micrograms/kg orciprenaline produced typical changes in carbohydrate and fat metabolism due to beta-adrenergic stimulation. Pretreatment with intravenously administered propranolol or metoprolol significantly inhibited orciprenaline-induced changes in systolic blood pressure, heart rate and plasma FFA, potassium, glucose and glycerol levels. Propranolol (0.1 mg/kg) seemed to be more effective than metoprolol (0.2 mg/kg) even in inhibiting predominantly beta 1-adrenergic responses.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Propranolol	Approved Investigational	Potassium	decreased	Propranolol decreases the level of Potassium in the blood
Propranolol	Approved Investigational	Glycerol	decreased	Propranolol decreases the level of Glycerol in the blood
Metoprolol	Approved Investigational	Potassium	decreased	Metoprolol decreases the level of Potassium in the blood
Metoprolol	Approved Investigational	Glycerol	decreased	Metoprolol decreases the level of Glycerol in the blood
Metoprolol	Approved Investigational	Free fatty acids	decreased	Metoprolol decreases the level of Free fatty acids in the blood
Metoprolol	Approved Investigational	Glucose	decreased	Metoprolol decreases the level of Glucose in the blood
Propranolol	Approved Investigational	Glucose	decreased	Propranolol decreases the level of Glucose in the blood
Propranolol	Approved Investigational	Free fatty acids	decreased	Propranolol decreases the level of Free fatty acids in the blood