Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000.
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Godsland IF
Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000.
Fertil Steril. 2001 May;75(5):898-915.
- PubMed ID
- 11334901 [ View in PubMed]
- Abstract
OBJECTIVE: To establish reference estimates of the effects of different hormone replacement therapy (HRT) regimens on lipid and lipoprotein levels. DESIGN: Review and pooled analysis of prospective studies published up until the year 2000. SETTING: Clinical trials centers, hospitals, menopause clinics. PATIENT(S): Healthy postmenopausal women. INTERVENTION(S): Estrogen alone, estrogen plus progestogen, tibolone, or raloxifene in the treatment of menopausal symptoms. MAIN OUTCOME MEASURE(S): Serum high- and low-density lipoprotein (HDL and LDL) cholesterol, total cholesterol, triglycerides, and lipoprotein (a). RESULT(S): Two-hundred forty-eight studies provided information on the effects of 42 different HRT regimens. All estrogen alone regimens raised HDL cholesterol and lowered LDL and total cholesterol. Oral estrogens raised triglycerides. Transdermal estradiol 17-beta lowered triglycerides. Progestogens had little effect on estrogen-induced reductions in LDL and total cholesterol. Estrogen-induced increases in HDL and triglycerides were opposed according to type of progestogen, in the order from least to greatest effect: dydrogesterone and medrogestone, progesterone, cyproterone acetate, medroxyprogesterone acetate, transdermal norethindrone acetate, norgestrel, and oral norethindrone acetate. Tibolone decreased HDL cholesterol and triglyceride levels. Raloxifene reduced LDL cholesterol levels. In 41 studies of 20 different formulations, HRT generally lowered lipoprotein (a). CONCLUSION(S): Route of estrogen administration and type of progestogen determined differential effects of HRT on lipid and lipoprotein levels. Future work will focus on the interpretation of the clinical significance of these changes.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Medrogestone Approved Withdrawn HDL cholesterol increased Medrogestone increases the level of HDL cholesterol in the blood Medrogestone Approved Withdrawn Triglycerides increased Medrogestone increases the level of Triglycerides in the blood Dydrogesterone Approved Investigational Withdrawn HDL cholesterol increased Dydrogesterone increases the level of HDL cholesterol in the blood Dydrogesterone Approved Investigational Withdrawn Triglycerides increased Dydrogesterone increases the level of Triglycerides in the blood Progesterone Approved Vet Approved HDL cholesterol increased Progesterone increases the level of HDL cholesterol in the blood Progesterone Approved Vet Approved Triglycerides increased Progesterone increases the level of Triglycerides in the blood Cyproterone acetate Approved Investigational HDL cholesterol increased Cyproterone acetate increases the level of HDL cholesterol in the blood Cyproterone acetate Approved Investigational Triglycerides increased Cyproterone acetate increases the level of Triglycerides in the blood Medroxyprogesterone acetate Approved Investigational HDL cholesterol increased Medroxyprogesterone acetate increases the level of HDL cholesterol in the blood Medroxyprogesterone acetate Approved Investigational Triglycerides increased Medroxyprogesterone acetate increases the level of Triglycerides in the blood Norgestrel Approved Triglycerides increased Norgestrel increases the level of Triglycerides in the blood Norethisterone Approved HDL cholesterol increased Norethisterone increases the level of HDL cholesterol in the blood Norethisterone Approved Triglycerides increased Norethisterone increases the level of Triglycerides in the blood Tibolone Approved Investigational HDL cholesterol decreased Tibolone decreases the level of HDL cholesterol in the blood Norgestrel Approved HDL cholesterol increased Norgestrel increases the level of HDL cholesterol in the blood Raloxifene Approved Investigational LDL cholesterol decreased Raloxifene decreases the level of LDL cholesterol in the blood Tibolone Approved Investigational Triglycerides decreased Tibolone decreases the level of Triglycerides in the blood