Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes.

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Hong SS, Lee JH, Jeong W, Kim N, Jin HZ, Hwang BY, Lee HJ, Lee SJ, Jang DS, Lee D

Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2347-9. doi: 10.1016/j.bmcl.2012.01.070. Epub 2012 Jan 28.

PubMed ID
22342624 [ View in PubMed
]
Abstract

A new acetylenic acid, (10E,14Z)-9-oxooctadeca-10,14-dien-12-ynoic acid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E,14Z)-9-hydroxyoctadeca-10,14-dien-12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-gamma with an EC(50) value of 1.88 muM as measured by a reporter gene assay. Expression of PPAR-gamma target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-gamma potential agonist that regulates transcription of the PPAR-gamma target genes.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
TroglitazonePeroxisome proliferator-activated receptor gammaEC 50 (nM)440N/AN/ADetails