Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

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Gitto R, Ferro S, Agnello S, De Luca L, De Sarro G, Russo E, Vullo D, Supuran CT, Chimirri A

Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

Bioorg Med Chem. 2009 May 15;17(10):3659-64. doi: 10.1016/j.bmc.2009.03.066. Epub 2009 Apr 7.

PubMed ID

19398204 [ View in PubMed

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Abstract

In previous studies we identified several 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives displaying potent anticonvulsant effects in different animal models of epilepsy. With the aim to deepen the structure-activity relationships (SAR) for this class of compounds and identify novel anticonvulsant agents we synthesized a series of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides. The new compounds incorporate the main features of the above-mentioned anticonvulsants and a sulfonamide function capable to inhibit the enzyme carbonic anhydrase (CA, EC 4.2.1.1), which represents an attractive target in epilepsy. Pharmacological effects were evaluated in vivo against audiogenic seizures in DBA/2 mice and in vitro against several CA isoforms. Some of the new molecules showed anticonvulsant properties better than topiramate, but weak inhibitory activity and low selectivity in enzymatic assay.

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Topiramate	Carbonic anhydrase 1	Ki (nM)	250	N/A	N/A	Details
Topiramate	Carbonic anhydrase 2	Ki (nM)	10	N/A	N/A	Details