3-Formylchromones: potential antiinflammatory agents.

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Khan KM, Ambreen N, Mughal UR, Jalil S, Perveen S, Choudhary MI

3-Formylchromones: potential antiinflammatory agents.

Eur J Med Chem. 2010 Sep;45(9):4058-64. doi: 10.1016/j.ejmech.2010.05.065. Epub 2010 Jun 8.

PubMed ID
20576329 [ View in PubMed
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Abstract

The synthesis and characterization of 3-formylchromone (1) and its derivatives 2-24 and evaluation of their potential antiinflammatory activities is reported here. These compounds were characterized by (1)H NMR, EI MS, IR, and UV spectroscopic techniques and elemental analysis. The synthesized compounds were evaluated by using various in vitro and in vivo assay models for antiinflammatory activity and their effects were compared with known standard drug such as aspirin and indomethacin. Among all tested compounds, 1, 2, 5, 6, 9, 14, 16-19, 21-23, showed promising antiinflammatory activities. The results and SAR has been discussed in this report.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Acetylsalicylic acidProstaglandin G/H synthase 1IC 50 (nM)750410N/AN/ADetails
Acetylsalicylic acidProstaglandin G/H synthase 2IC 50 (nM)1000000N/AN/ADetails
IndomethacinProstaglandin G/H synthase 1IC 50 (nM)50N/AN/ADetails
IndomethacinProstaglandin G/H synthase 2IC 50 (nM)670N/AN/ADetails