Triterpenoidal alkaloids from Buxus natalensis and their acetylcholinesterase inhibitory activity.

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Matochko WL, James A, Lam CW, Kozera DJ, Ata A, Gengan RM

Triterpenoidal alkaloids from Buxus natalensis and their acetylcholinesterase inhibitory activity.

J Nat Prod. 2010 Nov 29;73(11):1858-62. doi: 10.1021/np100494u. Epub 2010 Oct 18.

PubMed ID

20954721 [ View in PubMed

]

Abstract

Acetylcholinesterase (AChE) inhibition-directed phytochemical studies on the methanolic extract of Buxus natalensis, collected in South Africa, resulted in the isolation of 12 compounds: O(2)-natafuranamine (1), O(10)-natafuranamine (2), cyclonataminol (3), 31-demethylbuxaminol A (4), buxaminol A (5), buxafuranamide (6), buxalongifolamidine (7), buxamine A (8), cyclobuxophylline K (9), buxaminol C (10), methyl syringate (11), and p-coumaroylputrescine (12). Compounds 1-4 were new alkaloids, and compound 5 was isolated for the first time as a natural product. Their structures were elucidated with the aid of extensive NMR and mass spectroscopic studies. Compounds 1 and 2 are members of a rarely occurring class of Buxus alkaloids, having a tetrahydrofuran ring incorporated in their structures. Compounds 1-12 exhibited strong to moderate AChE inhibitory activity.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Galantamine	Acetylcholinesterase	IC 50 (nM)	530	N/A	N/A	Details
Huperzine A	Acetylcholinesterase	IC 50 (nM)	1700	N/A	N/A	Details