Sulfonamides as selective oestrogen receptor beta agonists.
Article Details
- CitationCopy to clipboard
Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M
Sulfonamides as selective oestrogen receptor beta agonists.
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. doi: 10.1016/j.bmcl.2011.08.041. Epub 2011 Aug 16.
- PubMed ID
- 21885279 [ View in PubMed]
- Abstract
A series of p-hydroxybenzenesulphonamides ERbeta receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERalpha receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERbeta agonists.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Estradiol Estrogen receptor EC 50 (nM) 0.046 N/A N/A Details Estradiol Estrogen receptor beta EC 50 (nM) 0.25 N/A N/A Details